PMID: 8949351Sep 1, 1996Paper

Glomerular nephropathy with IgA mesangium deposits and Crohn disease

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
A DabadieM Roussey

Abstract

Renal disease is an unfrequent extraintestinal manifestation of chronic inflammatory bowel disease. A 12-year-old girl suffered from recurrent abdominal pain, diarrhea and growth impairment due to Crohn's disease of ileocaecal region. After six months of nutritional rehabilitation, an ileo-caecal resection was performed because of intestinal stenosis. The surgical procedure was followed by parietal abcess and cutaneous fistula. One year later, a purulent secretion came out of the fistula associated with fever, hematuria and acute renal failure. Renal biopsy confirmed IgA nephropathy. The course was favorable under parenteral nutrition and after surgical closure of the sigmoido-cutaneous fistula. The microscopic hematuria only persisted but the nephropathy did not relapse even during a further digestive exacerbation. IgA nephropathy has been reported in association with chronic inflammatory bowel disease. Its mechanism remains unclear: increased mucosal IgA production in inflammatory bowel, increased serum IgA and/or immune complex deposition in the renal mesangium appear the most relevant hypotheses.

Citations

Jul 27, 2001·The American Journal of Gastroenterology·C Cucino, A Sonnenberg
Jul 27, 2006·International Urology and Nephrology·Aideloje OnimeAntonios H Tzamaloukas
May 8, 2010·Renal Failure·Vassilis FiliopoulosDimosthenis Vlassopoulos
Nov 1, 2014·CEN Case Reports·Midori HasegawaYukio Yuzawa
Dec 1, 2009·Clinical Journal of Gastroenterology·Yoshitaka UenoKazuaki Chayama
Feb 26, 2016·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Hemal N SampatBarbara Ostrov
Jan 9, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nizar JoherKhalil El Karoui
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrea J ShaerSally E Self

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