PMID: 15384010Sep 24, 2004Paper

Glomerular permeability activity: prevalence and prognostic value in pediatric patients with idiopathic nephrotic syndrome

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Howard TrachtmanV J Savin

Abstract

A circulating factor that increases in vitro glomerular permeability to albumin (P alb ) has been isolated from patients with recurrence of focal segmental glomerulosclerosis in their renal allografts. The prevalence and prognostic significance of permeability activity has not been examined in children with idiopathic nephrotic syndrome (INS). P alb activity level was determined in sera from 26 children with new-onset INS before the initiation of therapy by using an in vitro assay. Permeability factor was considered present if P alb was greater than 0.5. The following clinical and laboratory data for patients were tabulated: demographic information, serum albumin and cholesterol concentrations, calculated glomerular filtration rate, age at disease onset, response to corticosteroid treatment, and long-term outcome. Patients ranged in age from 2 to 18 years, and 19 patients (73%) were male. Mean P alb was 0.45 +/- 0.04 (SEM). P alb in patients with a steroid-responsive course (n = 17) did not differ from that of patients with steroid-resistant disease (n = 9). Percentages with P alb greater than 0.5 did not differ between patients with steroid-responsive and steroid-resistant disease (47% and 33%, respectively). P alb was determi...Continue Reading

Citations

Oct 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio Ponticelli
Nov 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rutger J MaasJack F Wetzels
Apr 4, 2014·Expert Opinion on Investigational Drugs·Valeria CernaroDomenico Santoro
Mar 6, 2007·Seminars in Nephrology·Melvin M Schwartz
Oct 24, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nidhi AggarwalVirginia J Savin
Dec 23, 2017·Journal of Nephrology·Duqun Chen, Weixin Hu
Sep 22, 2012·Journal of the American Society of Nephrology : JASN·Stephen M Korbet
Nov 19, 2004·Journal of the American Society of Nephrology : JASN·Steven W KraftEdmund J Lewis
Oct 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ellen T McCarthyVirginia J Savin
Oct 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Claudio Ponticelli, Richard J Glassock
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
Apr 5, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Marta AzocarFrancisco Cano

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