Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis

Journal of the American Society of Nephrology : JASN
T OdaN Yoshizawa

Abstract

A nephritogenic antigen for acute poststreptococcal glomerulonephritis (APSGN) was isolated recently from group A streptococcus and termed nephritis-associated plasmin receptor (NAPlr). In vitro experimental data indicate that the pathogenic role of NAPlr occurs through its ability to bind to plasmin and maintain its proteolytic activity. However, the mechanism whereby this antigen induces glomerular damage in vivo has not been fully elucidated. Renal biopsy tissues from 17 patients with APSGN, 8 patients with rapidly progressive glomerulonephritis, and 10 normal kidneys were analyzed in this study. Plasmin-like activity was assessed on cryostat sections by in situ zymography with a plasmin-sensitive synthetic substrate. Serial sections were simultaneously assessed for NAPlr deposition by immunofluorescence staining. Glomerular plasmin-like activity was absent or weak in normal controls and in patients with rapidly progressive glomerulonephritis, although tubulointerstitial activity was occasionally detected. Prominent glomerular plasmin-like activity was found in patients who had APSGN and in whom glomerular NAPlr was positive, whereas it was absent or weak in patients who had APSGN and in whom glomerular NAPlr was negative. T...Continue Reading

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Citations

Jan 29, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takashi OdaSoichiro Miura
Aug 18, 2005·Kidney International·Stephen R BatsfordBernardo Rodríguez-Iturbe
Jan 11, 2013·Kidney International·Samih H NasrVivette D D'Agati
Mar 7, 2006·Kidney International·N YoshizawaT Oda
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Jul 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T Matthew EisonRobert J Wyatt
Aug 1, 2008·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe, James M Musser
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Guoqiang ZhangAllison A Eddy
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Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Jan 23, 2021·International Journal of Molecular Sciences·Takashi Oda, Nobuyuki Yoshizawa

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