Glomerular proliferating cell kinetics in acute post-streptococcal glomerulonephritis (APSGN)

The Journal of Pathology
T OdaY Taguma

Abstract

To investigate the time sequence of glomerular cell proliferation in acute human glomerulonephritis, renal biopsy tissues were examined from 15 acute post-streptococcal glomerulonephritis (APSGN) patients (who were biopsied 1-31 days after onset), using an immunoperoxidase technique with monoclonal antibodies against proliferating cell nuclear antigen (PCNA) and various cell surface markers. Few, if any, PCNA+ cells were observed in normal glomeruli, but many cells were positive for PCNA in the acute phase of APSGN. Glomerular PCNA+ cells were observed either within glomerular tufts, or lining Bowman's capsule (parietal epithelial cells); the number of positive cells tended to decrease exponentially as the disease duration increased (r = -0.91, P < 0.0001). PCNA+ cells within glomerular tufts were further identified by double immunostaining. PCNA was not found in PMN or T cells, but a small proportion of macrophages were PCNA+. Most of the remaining PCNA+ cells were resident glomerular cells; the proportion of PCNA+ endothelial cells (CD31+) was over 80 per cent in the early phase, but as the disease continued the proportion of mesangial cells (alpha-smooth muscle actin+) increased to about half of the total PCNA+ cells within ...Continue Reading

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Citations

Mar 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Taketoshi KushiyamaHiroo Kumagai
Mar 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Qiong WuMasafumi Fukagawa
Sep 5, 2001·Kidney International·J Savill
Oct 23, 2009·Kidney International·Takamoto OhseStuart J Shankland
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S HisanoS Takebayashi
Jan 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takashi OdaSoichiro Miura
Mar 3, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Muneharu YamadaHiroo Kumagai
Dec 3, 2004·Journal of the American Society of Nephrology : JASN·Takashi OdaNobuyuki Yoshizawa
Apr 5, 2013·American Journal of Physiology. Renal Physiology·Taketoshi KushiyamaHiroo Kumagai
Jan 23, 2021·International Journal of Molecular Sciences·Takashi Oda, Nobuyuki Yoshizawa
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