Glomerulopathy with distinctive fibrillar deposits but lacking glomerular deposition of type III collagen

CEN Case Reports
Tatsuo YamamotoKunio Ohyama

Abstract

A 62-year-old woman with nephrotic syndrome underwent a renal biopsy. Under light microscopy, the biopsy findings included lobulation and enlargement of glomeruli, occasional thickening of glomerular capillary walls, and narrowing of the capillary lumen by swollen endothelial cells. Congo red staining was negative for amyloid. No significant intraglomerular fibrin deposition was found by phosphotungstic acid hematoxylin staining. Immunofluorescence microscopy showed no deposition of immunoglobulin G, A, or M; no κ or λ light chains; and no C3 or C1q. Electron microscopy revealed distinctive subendothelial and mesangial fibrillar deposits, mesangial cell interposition, and swelling and vacuolization of endothelial cells resulting in capillary lumen narrowing. Although some curvilinear fibrillar deposits mimicked the bundles of type III collagen fibers seen in collagenofibrotic glomerulopathy, neither glomerular deposition of type III collagen nor elevation of serum procollagen III peptide was noted. This glomerulopathy does not fulfill any known disease entities with non-amyloid non-immunoglobulin-derived organized glomerular deposits.

References

Jan 1, 1991·American Journal of Nephrology·E ImbasciatiM J Mihatsch
May 1, 1989·Kidney International·K YoshiokaS Maki
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·M BürginF Gloor
Feb 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B A VogtC E Kashtan
Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M C GublerR Habib
Apr 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H TamuraK Isoda
Nov 5, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·O SoylemezogluA M el Nahas
Mar 21, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Curtiss, J S Heilig
Feb 22, 2003·Virchows Archiv : an International Journal of Pathology·Hiroyuki MoritaAshio Yoshimura
Mar 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bassam AlchiFumitake Gejyo
Jun 15, 2007·Journal of the American Society of Nephrology : JASN·Samih H Nasr, Vivette D D'Agati
Feb 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroshi OhtaniKen-ichi Sawada
Mar 3, 2010·Ultrastructural Pathology·Shaila R KhubchandaniSwarnalata Gowrishankar
Mar 28, 2012·Advances in Chronic Kidney Disease·Arthur H Cohen
Feb 11, 2015·American Journal of Nephrology·Steven P SalvatoreSurya V Seshan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved