GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia

BMC Complementary and Alternative Medicine
Gulzar Ahmad BhatBilal Ahmad Paray

Abstract

Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of Momordica charantia (AEMC) on fasting blood glucose (FBG), tissue glycogen, glycosylated haemoglobin, plasma concentrations of insulin and GLP-1 hormone (glucagon-like peptide 1) in healthy and diabetic wistar rats. Male Wistar rats (both normal and diabetic) were treated with AEMC by gavaging (300 mg/kg body wt/day for 28 days). AEMC was found to increase tissue glycogen, serum insulin and GLP-1 non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats, whereas decrease in FBG and Glycosylated haemoglobin non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats. The elevation of GLP-1 level in normal and diabetic treated groups may be due to the L-cell regeneration and proliferation by binding with L-cell receptors and makes a conformational change, resulting in the activation of a series of signal transducers. The polar molecules of M. charantia also depolarize the L-cell through elevation of intracellular Ca2+ concentration and which in turn releases GLP-...Continue Reading

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Citations

Jun 8, 2018·BMC Complementary and Alternative Medicine·Gulzar Ahmad BhatBilal Ahmad Paray
Jun 14, 2018·BMC Complementary and Alternative Medicine·Gulzar Ahmad BhatBilal Ahmad Paray
Mar 19, 2021·Journal of Medicinal Food·Marisol Cortez-NavarreteKarina G Pérez-Rubio

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Methods Mentioned

BETA
enzyme linked immunosorbent assay

Software Mentioned

SPSS
AEMC

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