GluA1 phosphorylation alters evoked firing pattern in vivo.

Neural Plasticity
Balázs BarkócziViktor Szegedi

Abstract

AMPA and NMDA receptors convey fast synaptic transmission in the CNS. Their relative contribution to synaptic output and phosphorylation state regulate synaptic plasticity. The AMPA receptor subunit GluA1 is central in synaptic plasticity. Phosphorylation of GluA1 regulates channel properties and trafficking. The firing rate averaged over several hundred ms is used to monitor cellular input. However, plasticity requires the timing of spiking within a few ms; therefore, it is important to understand how phosphorylation governs these events. Here, we investigate whether the GluA1 phosphorylation (p-GluA1) alters the spiking patterns of CA1 cells in vivo. The antidepressant Tianeptine was used for inducing p-GluA1, which resulted in enhanced AMPA-evoked spiking. By comparing the spiking patterns of AMPA-evoked activity with matched firing rates, we show that the spike-trains after Tianeptine application show characteristic features, distinguishing from spike-trains triggered by strong AMPA stimulation. The interspike-interval distributions are different between the two groups, suggesting that neuronal output may differ when new inputs are activated compared to increasing the gain of previously activated receptors. Furthermore, we ...Continue Reading

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C M Gray, W Singer
Aug 1, 1995·Current Opinion in Neurobiology·G Buzsáki, J J Chrobak
Jul 1, 1994·Physiological Reviews·C J McBain, M L Mayer
Aug 20, 1993·Science·M A Wilson, B L McNaughton
Jan 1, 1993·Annual Review of Neuroscience·N W DawK Fox
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V DerkachT R Soderling
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·D A HoffmanB Sakmann
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Mar 30, 2004·Nature Neuroscience·Alanna J WattGina G Turrigiano
Aug 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wolfram B SchmittDavid M Bannerman
Dec 20, 2007·The European Journal of Neuroscience·Per SvenningssonPaul Greengard
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cassandra L KussiusGabriela K Popescu
Jan 7, 2010·Journal of Sleep Research·Roelina HagewoudPeter Meerlo

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Citations

Jun 13, 2015·European Journal of Pharmacology·David CavallaNephtali Marina
Oct 1, 2013·Reviews in the Neurosciences·Jingli Zhang, Jafri Malin Abdullah

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