Glucagon and fasting do not activate peroxisomal fatty acid beta-oxidation in rat liver

Archives of Biochemistry and Biophysics
R W Slauter, R K Yamazaki

Abstract

In a study of the endocrine control of peroxisomes, the effects of acute glucagon treatment and fasting on hepatic peroxisomal beta-oxidation in rats have been investigated. The activity of the rate-limiting peroxisomal beta-oxidation enzyme, fatty acyl-CoA oxidase, was measured to determine whether activation of peroxisomal beta-oxidation could account for the increase in total hepatic fatty acid oxidation following acute glucagon exposure. Catalase, a peroxisomal enzyme not directly involved in beta-oxidation, was also measured as a control for total peroxisomal activity. No changes with acute glucagon treatment of intact animals were observed with either activity as measured in liver homogenates or partially purified peroxisomal fractions. These observations indicate the lack of acute control by glucagon of peroxisomal function at the level of total enzyme activity. Previous work on the effects of fasting on hepatic fatty acid beta-oxidation [H. Ishii, S. Horie, and T. Suga (1980) J. Biochem. 87, 1855-1858] suggested an enhanced role for the peroxisomal beta-oxidation pathway during starvation. It was found that the peroxisomal beta-oxidation system, as measured by fatty acyl-CoA oxidase activity, does increase with duration...Continue Reading

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Jan 13, 1987·Biochimica Et Biophysica Acta·R Hertz, J Bar-Tana
Feb 19, 1988·Biochimica Et Biophysica Acta·F A ReubsaetL A Monnens
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Oct 25, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Melissa M PageJeffrey A Stuart
Aug 21, 2014·PloS One·Samuel RommelaerePhilippe Naquet

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