Glucagon and hyperglycaemia in diabetes

Clinical Science
Philip E Cryer

Abstract

Glucagon, in the setting of absolute or relative insulin deficiency, is thought to contribute to the pathogenesis of hyperglycaemia in diabetes, but much of the evidence is extrapolated from short-term studies to the long-term condition. In the present issue of Clinical Science, Li and co-workers report that infusion of glucagon raised fasting plasma glucose concentrations and impaired glucose tolerance over 4 weeks in mice, thus demonstrating a sustained glycaemic effect of hyperglucagonaemia. Nonetheless, compelling evidence that glucagon contributes to the pathogenesis of hyperglycaemia in diabetes awaits long-term selective reduction of glucagon secretion or action in humans.

Citations

Aug 17, 2011·Diabetes, Obesity & Metabolism·J N WalkerP Rorsman
Jan 1, 2010·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Fuad LechinMarcel E Lechin
Oct 30, 2009·Proceedings. Biological Sciences·J A Stoltz, M C B Andrade
Sep 14, 2010·Biochemical and Biophysical Research Communications·Mitsuru ShimamuraAkira Shinagawa
Apr 6, 2016·Upsala Journal of Medical Sciences·Linford BriantPatrik Rorsman
Jan 24, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Martin KöhlerPer-Olof Berggren
Jan 5, 2013·Epidemiology and Infection·E D FosterP M Polgreen
Jul 11, 2013·American Journal of Therapeutics·Fuad LechinBetty Pardey-Maldonado

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