Glucagon and insulin response to meals in non-obese and obese Dutch women

Clinica Chimica Acta; International Journal of Clinical Chemistry
P HillF de Waard


Many digestive complaints are associated with abnormalities in gastrointestinal peptide hormone function. To investigate the effect of obesity on the release of pancreatic peptide hormones, we have compared the release of insulin and glucagon in non-obese-obese Dutch women in response to isocaloric mixed meals and to Naloxone, an opioid antagonist. Healthy premenopausal women who were separated into three groups based on body mass index (BMI less than 23; 23-27, greater than 28), were fed 600-calorie breakfasts. Higher fasting levels of plasma insulin and glucagon occurred in obese (BMI greater than 28) than lean (BMI less than 23) women, while glucagon and insulin release after a high fat meal occurred in obese women. Naloxone administration in obese women decreased plasma insulin and glucagon, but in lean women, naloxone increased plasma glucagon but did not alter plasma insulin levels. Results indicate differences in opiate effects on pancreatic function in non-obese-obese women.


Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·H H HatfieldR K Kalkhoff
Dec 28, 1978·Histochemistry·D GrubeE Weber
Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J F BruniS S Yen
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·A GolayG M Reaven
Jun 1, 1986·Appetite·A W Logue, M E Smith
Apr 19, 1980·Lancet·M KyriakidesB Laurance
May 21, 1983·Lancet·R J Wurtman
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J E MorleyA A Varner
Feb 17, 1983·The New England Journal of Medicine·M FeldmanC H Li
Nov 1, 1983·The American Journal of the Medical Sciences·V V GossainD Turek
Dec 1, 1983·Clinical Endocrinology·F P AlfordS Whitehouse
May 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J R GivensA E Kitabchi
Jan 1, 1983·Journal of Pediatric Gastroenterology and Nutrition·J J Herbst, J K Harnsberger
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·I L Taylor, M Feldman
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R L Reid, S S Yen
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·B C HansenR A Wolfe

Related Concepts

Dietary Carbohydrates
Insulin B Chain

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.