Glucagon-based therapy: Past, present and future

Peptides
Mohan PatilGanesh V Sangle

Abstract

Diabesity and its related cardio-hepato-renal complications are of absolute concern globally. Last decade has witnessed a growing interest in the scientific community in investigating novel pharmaco-therapies employing the pancreatic hormone, glucagon. Canonically, this polypeptide hormone is known for its use in rescue treatment for hypoglycaemic shocks owing to its involvement in the counter-regulatory feedback mechanism. However, substantial studies in the recent past elucidated the pleiotropic effects of glucagon in diabesity and related complications like non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD). Thus, the dual nature of this peptide has sparked the search for drugs that can modify glucagon signalling to combat hypoglycaemia or diabesity. Thus far, researchers have explored various pharmacological approaches to utilise this peptide in imminent modern therapies. The research endeavours in this segment led to explorations of stable glucagon formulations/analogues, glucagon receptor antagonism, glucagon receptor agonism, and incretin poly-agonism as new strategies for the management of hypoglycaemia or diabesity. This 'three-dimensional' research on glucagon resulted in the discovery ...Continue Reading

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Citations

Jul 29, 2020·The Journal of Pharmacology and Experimental Therapeutics·Mitsugi OokawaraYusuke Moritoh
Oct 21, 2020·Critical Reviews in Food Science and Nutrition·Yang YangQing Zhou
Jan 29, 2021·Science Translational Medicine·Caitlin L MaikawaEric A Appel
Jul 2, 2021·Frontiers in Molecular Biosciences·Walter CabriAlessandra Tolomelli

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