Glucagon-like peptide-1-(7-36) amide and peptide YY mediate intraduodenal fat-induced inhibition of acid secretion in dogs

Endocrinology
L FungG R Greenberg

Abstract

Intraduodenal fat inhibits gastric acid secretion via the release of one or more hormonal enterogastrones thought to arise from ileocolonic mucosa. This study determined whether glucagon-like peptide-1 (GLP-1)-(7-36) amide and peptide YY (PYY), colocalized in L cells found in the ileum, mediate intraduodenal fat-induced inhibition of stimulated gastric acid, and evaluated the influence of cholecystokinin-A (CCK-A) receptor activation. Gastric acid secretion in response to duodenal perfusions of 8% peptone was measured in conscious dogs with gastric and duodenal cannulas. Intraduodenal administration of a 10% fat emulsion suppressed gastric acid secretion by 72 +/- 4% (P < 0.001) and increased plasma levels of GLP-1 and PYY by 44 +/- 5 and 46 +/- 4 fmol/ml, respectively (both P < 0.01). Pretreatment with the CCK-A receptor antagonist MK-329 completely reversed the inhibition of gastric acid by fat, suppressed rises of plasma GLP-1 (maximum change, 23 +/- 4 fmol/ml), and reduced plasma PYY responses to baseline. Intravenous infusions of 50 pmol/kg x h GLP-1 or PYY, which reproduced plasma elevations after intraduodenal fat, inhibited gastric acid secretion by 66 +/- 5% and 51 +/- 6%, respectively (both P < 0.01); coinfusions of G...Continue Reading

References

Jan 1, 1991·Scandinavian Journal of Gastroenterology·R LethL Olbe
Apr 1, 1991·Gastroenterology·J W WileyO Y Chung
May 1, 1990·Scandinavian Journal of Gastroenterology·R EisseleR Arnold
Jan 1, 1986·The Journal of Clinical Investigation·T N PappasI L Taylor
Mar 1, 1989·Endocrinology·G H GreeleyJ C Thompson
May 1, 1984·The Journal of Clinical Investigation·A H SollJ D Elashoff
Nov 1, 1983·Canadian Journal of Physiology and Pharmacology·K E HallN E Diamant
Apr 1, 1993·Digestive Diseases and Sciences·A WettergrenJ J Holst
Nov 1, 1995·Pflügers Archiv : European journal of physiology·X Fu-ChengC Rozé
Jun 1, 1997·Scandinavian Journal of Gastroenterology·A WettergrenJ J Holst

❮ Previous
Next ❯

Citations

Jul 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dominique DardevetAlan D Cherrington
Nov 14, 2008·Current Gastroenterology Reports·Mitchell L Schubert
Mar 11, 2005·Diabetes/metabolism Research and Reviews·Juris J Meier, Michael A Nauck
Mar 25, 2005·Diseases of the Colon and Rectum·Nahm-Gun OhThomas E Adrian
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Connie Chisholm, Gordon R Greenberg
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keishi KawakuboYvette Taché
Mar 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C Chisholm, G R Greenberg
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Carolyn F DeaconJens J Holst
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·E E DanielT J McDonald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.