Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT2c ) Receptor Agonists in the Ventral Tegmental Area (VTA) Inhibit Ghrelin-Stimulated Appetitive Reward

International Journal of Molecular Sciences
Erin HowellPaul J Currie

Abstract

Current literature indicates that the orexigenic peptide ghrelin increases appetitive motivation via signaling in the mesolimbic reward system. Another gastric peptide, glucagon-like peptide-1 (GLP-1), and the neurotransmitter 5-hydroxytryptamine (5-HT), are both known to suppress operant responding for food by acting on key mesolimbic nuclei, including the ventral tegmental area (VTA). In order to investigate the interaction effects of ghrelin, GLP-1, and 5-HT within the VTA, we measured operant responding for sucrose pellets after the administration of ghrelin, the GLP-1 receptor agonist exendin-4 (Ex-4), and the 5-HT2c receptor agonist Ro60-0175 in male Sprague-Dawley rats. Following training on a progressive ratio 3 (PR3) schedule, animals were first injected with ghrelin into the VTA at doses of 3 to 300 pmol. In subsequent testing, separate rats were administered intraperitoneal (IP) Ex-4 (0.1⁻1.0 µg/kg) or VTA Ex-4 (0.01⁻0.1 µg) paired with 300 pmol ghrelin. In a final group of rats, the 5-HT2c agonist Ro60-0175 was injected IP (0.25⁻1.0 mg/kg) or into the VTA (1.5⁻3.0 µg), and under both conditions paired with 300 pmol ghrelin delivered into the VTA. Our results indicated that ghrelin administration increased operant re...Continue Reading

References

Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Paul J CurrieFarnoosh Farahmand
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J FletcherGuy A Higgins
May 5, 2005·The European Journal of Neuroscience·Richard HsuRonald S Duman
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Jun 25, 2010·Pharmacology, Biochemistry, and Behavior·Paul J CurrieKatherine E Loera
Jan 3, 2012·Endocrinology·Karolina P SkibickaSuzanne L Dickson
Mar 1, 2012·Psychopharmacology·Gunnar SørensenDavid P D Woldbye
Dec 12, 2012·Psychoneuroendocrinology·Emil EgeciogluElisabet Jerlhag
Mar 21, 2013·Behavioural Brain Research·Sagar J DesaiDadasaheb M Kokare
Nov 22, 2014·Diabetes·Jeffrey GagnonPatricia L Brubaker
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Jul 18, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G van der PlasseR A H Adan
Aug 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhi-Bing YouRoy A Wise
Oct 2, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rozita H AnderbergKarolina P Skibicka
Oct 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jörgen A EngelElisabet Jerlhag
Nov 26, 2015·Hormones and Behavior·Veronique St-OngeAlfonso Abizaid
Dec 18, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heath D SchmidtMatthew R Hayes
Jan 16, 2016·Disease Models & Mechanisms·Malgorzata S Martin-GronertSusan E Ozanne
Jan 23, 2016·Endocrinology and Metabolism·Ye Ran Yoon, Ja Hyun Baik
Jan 24, 2016·Behavioural Brain Research·Megan J DaileyAlexander W Johnson
Feb 9, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rahul PanditRoger A H Adan
Apr 30, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caleb J Browne, Paul J Fletcher
Nov 25, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lourdes Valencia-TorresLora K Heisler
May 5, 2017·Journal of Neurophysiology·Katherine Stuhrman West, Aaron G Roseberry
Jul 5, 2017·Frontiers in Endocrinology·Andreas LindqvistNils Wierup

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Citations

Apr 20, 2020·Experimental Physiology·Houda NashawiElizabeth G Mietlicki-Baase
Jan 24, 2021·General and Comparative Endocrinology·Mauro ChiviteJesús M Míguez
Apr 4, 2021·Nutrients·Lea Decarie-Spain, Scott E Kanoski
Oct 28, 2019·Trends in Endocrinology and Metabolism : TEM·Philibert DuriezVirginie Tolle
Jun 22, 2021·The Journal of Physiology·Orla R M WoodwardJo E Lewis
Aug 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emanuela Micioni Di BonaventuraMaria Vittoria Micioni Di Bonaventura

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