Abstract
Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut after luminal stimulation. The hormone is a potent insulin secretagogue and is a potential novel pharmaceutical adjuvant in the treatment of NIDDM. Insulin is secreted as a series of punctuated secretory bursts superimposed on a basal insulin release. Recently, the contribution of these secretory bursts to overall insulin secretion has been evaluated, and studies using catheterization across the pancreas in a canine model and studies using deconvolution in humans have revealed that the majority of insulin is released during these secretory bursts. Moreover, the main regulation of insulin secretion is through perturbation of mass and frequency of these secretory bursts. The mode of delivery of insulin into the circulation seems important for insulin action, and it is therefore important to know the impact of a potential therapeutic insulin secretagogue on the mode of insulin secretion. To assess the effects of GLP-1 on the mass, frequency, amplitude, and overall contribution of pulsatile insulin secretion, we used a recently validated deconvolution model to examine these variables before and during infusion of GLP-1 in eight healthy men (age 28 +/...Continue Reading
Citations
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·M E Patti, C R Kahn
Mar 17, 2000·Anesthesiology·J BruhnA Hoeft
May 19, 2009·Medical Hypotheses·M Reza MirbolookiJonathan R T Lakey
Oct 9, 2012·Diabetes, Obesity & Metabolism·J J MeierJ D Veldhuis
Feb 1, 2015·Molecular Aspects of Medicine·Leslie S SatinArthur S Sherman
Mar 5, 2003·Pharmacological Reviews·Máire E Doyle, Josephine M Egan
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Hans-Georg JoostBernard Thorens
Jun 27, 2000·Diabetes/metabolism Research and Reviews·P Bergsten
Jan 30, 2002·Diabetes·Niels PørksenOle Schmitz
Mar 11, 2005·Diabetes/metabolism Research and Reviews·Juris J Meier, Michael A Nauck
Jun 25, 2016·Islets·Joshua A LevineBarton Wicksteed
Apr 6, 2001·Diabetes·R RitzelM A Nauck
Jul 27, 2001·Diabetes·C B JuhlO Schmitz
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Suzanne RogersJames D Best
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·R A RitzelP C Butler
Jan 20, 2006·Nature·Oleg DyachokAnders Tengholm
May 28, 2005·Diabetes·Juris J MeierPeter C Butler
Nov 10, 2005·Journal of Endocrinological Investigation·C M RotellaE Mannucci
Nov 11, 2009·Acta Biochimica Et Biophysica Sinica·Hu ZhouKan Liao
Mar 18, 2020·JCI Insight·Marcello C LaurentiAdrian Vella