Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Incident Diabetic Retinopathy
Abstract
Previous studies suggested that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) may initially worsen and possibly increase the risk of diabetic retinopathy. However, data on this possible association remain limited. Thus, this population-based study aimed to determine whether use of GLP-1 RAs is associated with an increased risk of incident diabetic retinopathy. Using the U.K. Clinical Practice Research Datalink (CPRD), we conducted a cohort study among 77,115 patients with type 2 diabetes initiating antidiabetic drugs between January 2007 and September 2015. Adjusted hazard ratios (HRs) and 95% CIs of incident diabetic retinopathy were estimated using time-dependent Cox proportional hazards models, comparing use of GLP-1 RAs with current use of two or more oral antidiabetic drugs. In an ancillary analysis, new users of GLP-1 RAs were compared with new users of insulin. During 245,825 person-years of follow-up, 10,763 patients were newly diagnosed with diabetic retinopathy. Compared with current use of two or more oral antidiabetic drugs, use of GLP-1 RAs was not associated with an increased risk of incident diabetic retinopathy overall (HR 1.00, 95% CI 0.85-1.17). Compared with insulin, GLP-1 RAs were associated with a d...Continue Reading
References
Validation and validity of diagnoses in the General Practice Research Database: a systematic review.
The impact of improved glycaemic control with GLP-1 receptor agonist therapy on diabetic retinopathy
Citations
Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management.
Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management.
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