Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jean-Philippe KriegerShin J Lee

Abstract

Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose metabolism via vagal afferent neurons (VANs). Recently, VANs have received increasing attention for their role in brown adipose tissue (BAT) thermogenesis. It is, however, unclear whether VAN GLP-1 receptor (GLP-1R) signaling affects BAT thermogenesis and energy expenditure (EE) and whether this VAN mechanism contributes to energy balance. First, we tested the effect of the GLP-1R agonist exendin-4 (Ex4, 0.3 μg/kg ip) on EE and BAT thermogenesis and whether these effects require VAN GLP-1R signaling using a rat model with a selective Glp1r knockdown (kd) in VANs. Second, we examined the role of VAN GLP-1R in energy balance during chronic high-fat diet (HFD) feeding in VAN Glp1r kd rats. Finally, we used viral transsynaptic tracers to identify the possible neuronal substrates of such a gut-BAT interaction. VAN Glp1r kd attenuated the acute suppressive effects of Ex4 on EE and BAT thermogenesis. Consistent with this finding, the VAN Glp1r kd increased EE and BAT activity, diminished body weight gain, and improved insulin sensitivity compared with HFD-fed controls. Anterograde transsynaptic viral tracing of VANs infected major hypothalamic and hin...Continue Reading

References

Jun 11, 1999·The American Journal of Physiology·M BamshadT J Bartness
Oct 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J Madden, S F Morrison
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda Rinaman, Gary Schwartz
Dec 26, 2006·The Journal of Clinical Investigation·Tanya HansotiaDaniel J Drucker
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne M AppleyardMichael C Andresen
May 17, 2008·Regulatory Peptides·Hans-Rudolf Berthoud
Jan 9, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J Madden, S F Morrison
Mar 17, 2010·Physiology & Behavior·Matthew R HayesScott E Kanoski
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah StanleyJeffrey M Friedman
Apr 9, 2010·Cell Metabolism·Leslie P Kozak
Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei-Hua CaoShaun F Morrison
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason G BarreraRandy J Seeley
Jan 22, 2013·Frontiers in Neuroscience·Michael C AndresenMackenzie E Hofmann
Feb 1, 2014·Methods in Enzymology·Sebastian D ParleeOrmond A MacDougald
Mar 19, 2014·Cell Metabolism·Shaun F MorrisonDomenico Tupone
Apr 8, 2014·Cell Metabolism·Chen LiuJoel K Elmquist
May 23, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melanie KlarerUrs Meyer
Sep 10, 2014·The Journal of Clinical Investigation·Anna SecherLotte Bjerre Knudsen
Jun 7, 2015·Physiology & Behavior·Jean-Philippe KriegerShin J Lee
Sep 5, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fei WangPatrick Tso
Mar 10, 2016·The Journal of Physiology·Guillaume de Lartigue
Jun 16, 2016·Cell Metabolism·Wan-Hui LiaoWolfgang Langhans
Jun 30, 2016·American Journal of Physiology. Endocrinology and Metabolism·Christopher J Madden, Shaun F Morrison
Sep 7, 2016·Current Opinion in Pharmacology·Guillaume de Lartigue, Charlene Diepenbroek
Mar 30, 2017·Temperature : Multidisciplinary Biomedical Journal·Christopher J MaddenShaun F Morrison
Jun 20, 2017·The Journal of Clinical Investigation·Zhigang ShiVirginia L Brooks

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Citations

Jul 17, 2019·American Journal of Physiology. Endocrinology and Metabolism·Fitore RakaKhosrow Adeli
Feb 13, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Willis K Samson
May 7, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gina L C Yosten
Nov 30, 2019·Nature Reviews. Endocrinology·Chelsea M LarabeeAna I Domingos
Aug 16, 2018·Frontiers in Endocrinology·Stewart ChristieAmanda J Page
Jun 6, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Willis K SamsonGina L C Yosten
May 20, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Andrew English, Nigel Irwin
Jul 1, 2020·Frontiers in Physiology·Yoko B WangAmanda J Page
Jun 14, 2019·Obesity Surgery·Gian Franco AdamiRenzo Cordera
Nov 27, 2019·Molecular Metabolism·T D MüllerM H Tschöp
Feb 12, 2021·Nature Communications·Frank A DucaTony K T Lam
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans
Aug 17, 2021·Physiological Reviews·Willis K SamsonCarol Ann Remme
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He
Sep 15, 2021·British Journal of Pharmacology·Anita KabahiziKevin W Williams
Dec 31, 2021·The Journal of Clinical Endocrinology and Metabolism·Alev Eroglu Altinova

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Methods Mentioned

BETA
PCR
dissection
laser capture microdissection

Software Mentioned

Image J
EthoVision
FLIR Tool
SPSS Statistics
GraphPad Prism
Dataquest ART ( DSI

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