Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice

Gut
Jesper ThulesenSteen Seier Poulsen

Abstract

Glucagon-like peptide 2 (GLP-2) is an intestinotrophic mediator with therapeutic potential in conditions with compromised intestinal capacity. However, growth stimulation of the intestinal system may accelerate the growth of existing neoplasms in the intestine. In the present study, the effects of GLP-2 treatment on the growth of chemically induced colonic neoplasms were investigated. In 210 female C57bl mice, colonic tumours were initially induced with the methylating carcinogen 1,2-dimethylhydrazine (DMH) and mice were then treated with GLP-2. Two months after discontinuation of the carcinogen treatment, 135 of the mice were allocated to one of six groups which were treated twice daily with 25 microg GLP-2, 25 microg Gly2-GLP-2 (stable analogue), or phosphate buffered saline for a short (10 days) or long (one month) period. The remaining 75 mice had a treatment free period of three months and were then allocated to groups subjected to long term treatment, as above. Colonic polyps developed in 100% of the mice, regardless of treatment. Survival data revealed no statistical significant differences among the different groups but histopathological analysis demonstrated a clear and significant increase in tumour load of mice treat...Continue Reading

References

Dec 1, 1985·Digestive Diseases and Sciences·A E Rogers, K M Nauss
Feb 1, 1985·Digestive Diseases and Sciences·S S PoulsenP Kirkegaard
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J DruckerP L Brubaker
Oct 1, 1998·Scandinavian Journal of Gastroenterology·M WøjdemannJ J Holst
Nov 14, 1998·The American Journal of Physiology·R B ScottJ B Meddings
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D G MunroeA Crivici
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·M WøjdemannJ J Holst
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Bjerknes, H Cheng
Oct 18, 2001·Journal of the National Cancer Institute·C ColussiM Bignami

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Citations

Jun 26, 2012·Cancer Chemotherapy and Pharmacology·Hannelouise KissowSteen Seier Poulsen
Sep 27, 2005·Digestive Diseases and Sciences·Ryuichi Okamoto, Mamoru Watanabe
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Katharina WallisSimon Gabe
Apr 11, 2006·Annual Review of Nutrition·Jennifer L Estall, Daniel J Drucker
Jun 14, 2012·Endocrine-related Cancer·Roman VangoitsenhovenBart Van der Schueren
Jan 18, 2008·World Journal of Gastroenterology : WJG·Andreas Sturm, Axel U Dignass
Jan 20, 2009·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
Oct 29, 2013·Annual Review of Physiology·Daniel J Drucker, Bernardo Yusta
Feb 22, 2013·Journal of Clinical Gastroenterology·Kelly A TappendenBo Joelsson
Oct 25, 2011·Expert Review of Gastroenterology & Hepatology·Kishore Vipperla, Stephen J O'Keefe
Jan 10, 2012·Expert Opinion on Pharmacotherapy·Lærke Marijke NørholkPalle Bekker Jeppesen
Oct 19, 2013·Expert Review of Gastroenterology & Hepatology·Kishore Vipperla, Stephen J O'Keefe
Nov 9, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A PiniM G Vannucchi
Jun 12, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·André Van GossumUNKNOWN ESPEN
Mar 28, 2009·Cytokine & Growth Factor Reviews·Roger YazbeckCatherine A Abbott
Apr 12, 2008·Molecular and Cellular Endocrinology·Katherine J Rowland, Patricia L Brubaker
Aug 7, 2007·International Journal of Radiation Oncology, Biology, Physics·Valérie HaydontMarie-Catherine Vozenin-Brotons
May 8, 2007·Nutrition·Robert A Goodlad
Feb 18, 2016·Current Opinion in Organ Transplantation·Ulrich-Frank PapeAndreas Pascher
May 3, 2007·Gastroenterology Clinics of North America·Palle Bekker Jeppesen
Jan 16, 2007·Alimentary Pharmacology & Therapeutics·K WallisA Forbes
Sep 15, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Hideki YoshikawaYoshikatsu Eto
Nov 6, 2012·Alimentary Pharmacology & Therapeutics·P JanssenJ Tack
May 21, 2013·Journal of Diabetes·Yunjuan ZhaoZhiguang Zhou
Feb 14, 2006·Gastroenterology·Palle Bekker Jeppesen
Nov 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Sandra TorresAgnès François
Apr 16, 2013·Pharmacology & Therapeutics·Vinicius KannenAna Maria Waaga-Gasser
Sep 7, 2012·Molecular and Cellular Endocrinology·Meike KörnerJean Claude Reubi
Apr 15, 2015·Current Opinion in Supportive and Palliative Care·Hannelouise Kissow
Oct 23, 2012·Gut·Hannelouise KissowSteen Seier Poulsen
Jul 8, 2008·Lancet·Laurent Peyrin-BirouletJean-Frédéric Colombel
Jun 22, 2016·Current Gastroenterology Reports·Robert E CarrollAlan L Buchman
Oct 23, 2016·Cancer Chemotherapy and Pharmacology·Bronwen J MayoDorothy M Keefe
Jun 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Paul A KitchenJulian R F Walters
Mar 25, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F LiS Qu

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