Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

S L ConarelloB B Zhang


Under normal physiological conditions, glucagon signalling is important in glucose homeostasis. Hyperglucagonaemia or altered insulin:glucagon ratio plays a role in maintaining hyperglycaemia in subjects with type 2 diabetes. It has been reported that glucagon receptor knockout (Gcgr (-/-)) mice develop normally and have lower plasma glucose on a normal diet. The goal of the current research was to further investigate the role of glucagon signalling in metabolic control and glucose homeostasis. Gcgr (-/-) mice were challenged with a high-fat diet (HFD) and with streptozotocin, which induces beta cell damage. They were then analysed for whole-body and serum metabolic phenotypes as well as pancreatic islet morphology. In comparison with wild-type mice, Gcgr (-/-) mice exhibited decreased body weight and food intake, reduced plasma glucose levels, and improved oral and intraperitoneal glucose tolerance. Elevated glucagon-like peptide-1 levels and reduced gastric emptying were also observed in Gcgr (-/-) mice, which also had reduced HFD-induced hyperinsulinaemia and hyperleptinaemia, and were resistant to the development of hepatic steatosis. In addition, Gcgr (-/-) mice were resistant to STZ-induced hyperglycaemia and pancreatic b...Continue Reading


Mar 1, 1992·Diabetes Care·A Consoli
Jan 1, 1997·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M A NauckW Schmiegel
Jul 1, 1999·Journal of Dairy Science·A R HippenR W Tucker
Aug 26, 2000·Current Opinion in Chemical Biology·B B Zhang, David E Moller
Oct 7, 2000·The Veterinary Clinics of North America. Food Animal Practice·A R Hippen
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·P ShahRobert A Rizza
Feb 13, 2001·Endocrinology·Daniel J Drucker
Jun 22, 2001·Journal of Clinical Gastroenterology·E D EhrenpreisR M Craig
Sep 7, 2001·Journal of Medicinal Chemistry·Anthony LingJ Lau
Jan 12, 2002·Biochemical and Biophysical Research Communications·Janice C ParkerJohn D McNeish
Feb 15, 2002·Bioorganic & Medicinal Chemistry Letters·Anthony LingAlex Polinsky
Aug 30, 2002·Metabolism: Clinical and Experimental·Ingrid ToftTrond Jenssen
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard W GellingMaureen J Charron
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·G Jiang, Bei B Zhang
May 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·S L ConarelloBei B Zhang
Mar 16, 2005·Treatments in Endocrinology·Laurie L Baggio, Daniel J Drucker
Aug 17, 2005·Bioorganic & Medicinal Chemistry Letters·Dong-Ming ShenE R Parmee


Dec 5, 2013·Physiological Reports·Auyon MukharjiSteven J Swoap
May 26, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y AniniM Mbikay
Oct 20, 2010·Nature Reviews. Endocrinology·Kirk M HabeggerMatthias Tschöp
Aug 17, 2011·Diabetes, Obesity & Metabolism·Patricia M Vuguin, Maureen J Charron
Aug 17, 2011·Diabetes, Obesity & Metabolism·David D'Alessio
Aug 17, 2011·Diabetes, Obesity & Metabolism·Y Hayashi
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Julie A Harney, Robert L Rodgers
Feb 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sheng-Song ChenOwen P McGuinness
Feb 15, 2011·Experimental Diabetes Research·Yuqing YangXianxin Hua
May 5, 2011·The Journal of Clinical Investigation·Safina AliDaniel J Drucker
Feb 2, 2012·Endocrinology·B J JonesS R Bloom
Jul 2, 2010·Molecular Endocrinology·Aidan S HancockCatherine L May
Sep 23, 2008·The Journal of Experimental Biology·K N BharuchaS L Zipursky
Feb 2, 2011·PloS One·Zhuo LiuJosephine M Egan
Apr 3, 2014·Comprehensive Physiology·Liangyou Rui
Jun 4, 2014·The Journal of Endocrinology·Hidetada OgataYutaka Oiso
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Young LeeRoger H Unger
Oct 13, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ande SatyanarayanaJonathan R Keller
Oct 18, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xianyang ZhangAndrew V Schally
Apr 2, 2015·Expert Opinion on Therapeutic Patents·Kevin J Filipski
May 30, 2015·The Journal of Endocrinology·Daniella B R InsuelaVinicius F Carvalho
Aug 1, 2012·Islets·Joel F Habener, Violeta Stanojevic
Jan 9, 2015·The Journal of Endocrinology·Maureen J Charron, Patricia M Vuguin
Jan 29, 2011·Diabetes·Dale S Edgerton, Alan D Cherrington
May 18, 2016·ELife·Lena Eliasson, Anna Wendt
Aug 23, 2008·Free Radical Biology & Medicine·Jing ChenClayton E Mathews
Sep 24, 2008·Gastroenterology·Elaine M SinclairDaniel J Drucker
Dec 16, 2016·International Journal of Molecular Sciences·Salvatore PettaFerruccio Bonino
Dec 18, 2015·Journal of Biomolecular Screening·Matthew R EvansMichael G Roth
Mar 18, 2017·Diabetes, Obesity & Metabolism·Manisha GargParesh Dandona
May 11, 2017·Diabetes·Bharath K ManiJeffrey M Zigman
Jul 29, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Melissa F BreretonAnne Clark
Jan 16, 2018·Expert Opinion on Investigational Drugs·Tongzhi WuMichael Horowitz
Oct 21, 2017·Expert Opinion on Investigational Drugs·André J ScheenPierre J Lefèbvre
Mar 10, 2017·Physiological Reviews·T D MüllerMatthias Tschöp
Oct 9, 2015·The Journal of Endocrinology·Mingyu LiWenbiao Chen
Oct 15, 2018·Journal of Cellular Physiology·Thiago R AraujoRosane Aparecida Ribeiro
Nov 16, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Myint Aung Moh MohJi-Oh Mok
Mar 2, 2019·Expert Opinion on Drug Discovery·Mar QuiñonesOmar Al-Massadi
Apr 12, 2014·Nutrition Research Reviews·Laura MarroquíIvan Quesada
Jul 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Pritpal Bansal, Q Wang
Jan 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Safina Ali, Daniel J Drucker
Apr 27, 2016·Diabetologia·Young H LeeRoger H Unger
Mar 20, 2014·British Journal of Pharmacology·D Kaiser, E Oetjen
Jun 28, 2014·Science China. Life Sciences·Jue Wang, RuiPing Xiao
Jun 14, 2014·Diabetes/metabolism Research and Reviews·Yuanyuan ChenJinhua Wen
Apr 3, 2015·Physiological Reviews·Darleen A Sandoval, David D'Alessio
Sep 22, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kyoung Moo ChoiGianrico Farrugia
Jan 26, 2020·International Journal of Molecular Sciences·Qi KangMingyu Li
Feb 19, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sean M Hartig, Aaron R Cox
Oct 28, 2019·Diabetes·E Danielle Dean
Apr 24, 2016·Cellular and Molecular Life Sciences : CMLS·Krishna PrasadanGeorge Gittes
Dec 19, 2018·Journal of the Endocrine Society·Takehiro KatahiraHirotaka Watada
Nov 2, 2012·American Journal of Physiology. Endocrinology and Metabolism·J PedersenJens J Holst
Mar 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Xiping ChengJesper Gromada
May 10, 2019·Frontiers in Physiology·Katrine D GalsgaardNicolai J Wewer Albrechtsen
Aug 14, 2019·International Journal of Molecular Sciences·Omar Al-MassadiMar Quiñones
Apr 20, 2014·The Journal of Biological Chemistry·Anita JohswichJames W Dennis
Feb 13, 2015·The Open Medicinal Chemistry Journal·Mohamed LotfyErnest Adeghate
Dec 26, 2017·Nutrition and Healthy Aging·Sadeesh K Ramakrishnan, Yatrik M Shah
Mar 29, 2019·Endocrine Reviews·Nicolai J Wewer AlbrechtsenJens Juul Holst
Oct 6, 2017·American Journal of Physiology. Endocrinology and Metabolism·Katrine D GalsgaardJens Juul Holst
Feb 19, 2021·Journal of Neuroendocrinology·Teppei Fujikawa
Jan 28, 2020·Seminars in Cell & Developmental Biology·Anna Wendt, Lena Eliasson
Feb 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·May-Yun WangWilliam L Holland
Jan 9, 2018·Mayo Clinic Proceedings·Sofie HædersdalTina Vilsbøll
Jun 10, 2021·Frontiers in Endocrinology·Jenna Elizabeth HuntHannelouise Kissow

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.