PMID: 6171260Feb 15, 1981Paper

Glucagon stimulation of ruthenium red-insensitive calcium ion transport in developing rat liver

The Biochemical Journal
P H Reinhart, F L Bygrave

Abstract

The maturation of glucagon-stimulated Ruthenium Red-insensitive Ca2+-transport activity was determined in livers of rats ranging in age from 5 days preterm to 10 weeks of adult life. Previous indications are that this activity is confined to vesicles derived mainly from the endoplasmic reticulum. Perinatal-rat liver contains near-adult values of Ruthenium Red-insensitive Ca2+-transport activity, and exhibits large transient increases in the rate of this activity at two stages of development, immediately after birth, and at 2-5 days after birth. The administration of glucagon to foetal rats, at developmental stages after 19.5 days of gestation (2.5 days before birth), results in a large stable increase (greater than 100%) of Ca2+-transport activity in a subsequently isolated 'heavy' microsomal fraction. That this fraction was enriched in vesicles derived from the rough endoplasmic reticulum was indicated by both an electron-microscopic examination and a marker-enzyme analysis of the subcellular fractions. The administration of glucagon into newborn animals only hours old does not enhance further the initial rate of Ca2+-transport activity, and from day 1 to 10 weeks after birth the administration of the hormone results in the mo...Continue Reading

Citations

Dec 15, 1993·European Journal of Biochemistry·F H van de PutP H Willems
Dec 1, 1995·European Journal of Biochemistry·M P De MoelP H Willems
Sep 4, 2004·Biochemical Pharmacology·Miklós CsalaBrian Burchell
Nov 1, 1984·Biological Reviews of the Cambridge Philosophical Society·P H ReinhartF L Bygrave
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kakoli MitraDonald M Engelman
Jul 1, 1990·Analytical Biochemistry·J H CharukR A Reithmeier
Oct 1, 1998·The American Journal of Physiology·C CefarattiA Scarpa
Jun 15, 1986·Biochemical Pharmacology·C Cambon-GrosS Mitjavila
Jul 1, 1983·Cell Calcium·N Kraus-Friedmann, P Zimniak
May 16, 1984·Biochemical and Biophysical Research Communications·A P Dawson, R F Irvine

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