Glucan-enhanced immunogenicity of killed erythrocyte stages of Plasmodium berghei.

Infection and Immunity
T W HolbrookB W Parker

Abstract

Intravenous injections of glucan simultaneously with Formalin-killed erythrocytic stages of Plasmodium berghei elicited a greater degree of resistance in mice against subsequent infection with viable parasites than injections of killed erythrocytic stages alone. In two experiments with P. berghei strain NK 65, 100% of mice immunized with the glucan-dead parasite preparation survived challenge, whereas only 28.6% of mice receiving dead parasites alone survived. In the third experiment, using P. berghei strain NYU-2, the same proportion of mice survived after immunization with glucan and dead parasites as with dead parasites alone (i.e., 10 of 11 in each group), but mice immunized with the glucan-dead parasite preparation experienced parasitemias of significantly less intensity and shorter duration than mice which received only dead parasites before infection. Inoculation of glucan alone or with normal erythrocytes conferred no protection against challenge.

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Citations

Apr 1, 1985·Annals of Tropical Medicine and Parasitology·P Kumar, S Ahmad
Jul 24, 2010·The Journal of Veterinary Medical Science·Jayanthe R P V RajapakseTakeshi Agatsuma
Jan 1, 1984·Journal of Immunopharmacology·H A PérezG San Blas
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·T W HolbrookB W Parker
Jul 28, 2018·Helminthologia·V Vetvicka, R Fernandez-Botran
Jan 1, 1984·International Journal of Immunopharmacology·A SharmaS Ahmad
Mar 1, 1982·Infection and Immunity·J L BenachJ A Cook
Sep 1, 1982·Infection and Immunity·J A CookW J Dougherty

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