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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

Neuron

Jan 4, 2020

Michael X HendersonVirginia M Y Lee

Abstract

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been linked to accumulation of α-synuclein. The current study ...read more

Mentioned in this Paper

Lysosomes
Dementia
Pathogenesis
Alpha-Synuclein
Neurons
Glucosylceramidase Activity
Pathology
Protein Aggregation, Pathological
Mouse Model
Astrocytes
40
1
Paper Details
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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

Neuron

Jan 4, 2020

Michael X HendersonVirginia M Y Lee

PMID: 31899072

DOI: 10.1016/j.neuron.2019.12.004

Abstract

Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been linked to accumulation of α-synuclein. The current study ...read more

Mentioned in this Paper

Lysosomes
Dementia
Pathogenesis
Alpha-Synuclein
Neurons
Glucosylceramidase Activity
Pathology
Protein Aggregation, Pathological
Mouse Model
Astrocytes
40
1

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