Glucocorticoid and mineralocorticoid receptor polymorphisms and recurrence of major depressive disorder

Psychoneuroendocrinology
Florian HardeveldAartjan T F Beekman

Abstract

Previous research found that variants of the glucocorticoid receptor (GR) (9β, ER22/23EK, BclI, TthIIIl, NR3C1-1 and N363S) and mineralocorticoid receptor (MR) gene polymorphism (-2 C/G and I180V) are associated with both glucocorticoid (GC) sensitivity and major depressive disorder (MDD). There are no data which investigated prospectively whether these variants are associated with recurrence of MDD. Data were derived from the Netherlands Study of Depression and Anxiety (NESDA) which used the Composite International Diagnostic Interview (CIDI) to determine MDD. Polymorphisms in the GR and MR gene were determined and haplotypes were characterized. We analyzed in retrospect whether recurrent MDD (n=951) in comparison with first onset MDD (n=919) was associated with polymorphisms in the GR and MR gene. Furthermore, we analyzed prospectively for 4 years the time to recurrence among 683 subjects with a remitted MDD diagnosis. Time to recurrence of MDD was assessed using the CIDI and a life chart interview. Additionally, we analyzed interactions of the investigated polymorphisms with childhood trauma and recent negative life events. GR and MR gene polymorphisms and derived haplotypes were not associated with recurrence of depression ...Continue Reading

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Citations

Feb 10, 2016·Frontiers in Behavioral Neuroscience·Sofia KanatsouMarian Joëls
Feb 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ji Sun Kim, Seung-Hwan Lee
Nov 8, 2015·Psychoneuroendocrinology·Fatima M KabiaHannie C Comijs
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Aug 16, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kim HinkelmannChristian Otte
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Jan 7, 2020·Acta Neuropsychiatrica·Caroline Normann, Henriette N Buttenschøn
May 21, 2019·Acta Neuropsychiatrica·Caroline Normann, Henriette N Buttenschøn
May 1, 2021·Translational Psychiatry·Mark D KvartaL Elliot Hong

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