Glucocorticoid and mineralocorticoid receptors and associated diseases

Essays in Biochemistry
Tomoshige Kino, George P Chrousos

Abstract

Adrenal corticosteroids, i.e. glucocorticoids and mineralocorticoids, play important physiological roles in humans. Their actions are mediated by intracellular receptor molecules, the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), which function as hormone-dependent transcription factors. Ligand-activated receptors modulate the transcription rates of responsive genes by interacting with responsive elements in the promoters of these genes or by influencing the activities of other transcription factors, via protein-protein interactions. Natural inactivating mutations of the GR or MR genes have been reported in humans with significant clinical phenotypes. The former causes sporadic or familial glucocorticoid resistance characterized by generalized partial insensitivity of tissues to glucocorticoids and subsequent activation of the hypothalamic/pituitary/adrenal axis with resultant hyperandrogenism in children and women and/or mineralocorticoid excess symptoms in both sexes. The latter develop pseudohypoaldosteronism type 1, i.e. hypotension and hyperkalaemic acidosis, as a result of reduced aldosterone actions in the kidney. An activating mutation in the MR gene causing early-onset, periodic hypertension was rep...Continue Reading

Citations

Oct 6, 2005·Science's STKE : Signal Transduction Knowledge Environment·George P Chrousos, Tomoshige Kino
Nov 13, 2009·Annals of the New York Academy of Sciences·George P Chrousos, Tomoshige Kino
Jul 28, 2009·Cellular and Molecular Life Sciences : CMLS·Tomoshige KinoGeorge P Chrousos
Nov 9, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Guoping CaoWenjun Fu
Feb 6, 2019·Nuclear Receptor Signaling·Rafah MackehTomoshige Kino
Mar 28, 2013·International Journal of Endocrinology·Monika Puzianowska-KuznickaJacek Polosak
Jun 6, 2019·Frontiers in Physiology·Juan Hernández-PérezMarcos A López-Patiño
May 12, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Qing-Qing LuoSheng-Liang Chen
May 19, 2005·Pharmacogenetics and Genomics·Allan B OkeyPatricia A Harper
May 22, 2007·Stress : the International Journal on the Biology of Stress·George P Chrousos, Tomoshige Kino
Jun 17, 2008·Human Reproduction Update·Anthony E Michael, Aris T Papageorghiou
Jun 4, 2014·Annals of the New York Academy of Sciences·Nicolas C NicolaidesTomoshige Kino
Mar 10, 2019·Nature Reviews. Endocrinology·Arno TéblickGreet Van den Berghe
Oct 1, 2020·BMC Endocrine Disorders·Flavio A Cadegiani
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nancy NaderTomoshige Kino
Jan 31, 2018·Journal of the Endocrine Society·Rafah MackehTomoshige Kino
Aug 2, 2021·Reviews in Endocrine & Metabolic Disorders·Berta SoldevilaMónica Marazuela
Jul 29, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Mi-Sook LeeSong Her

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