PMID: 3754603Jan 1, 1986Paper

Glucocorticoid control of developmentally regulated adipose genes

Journal of Steroid Biochemistry
G M RingoldD M Knight

Abstract

We have analyzed the hormonal basis for the acceleration of differentiation by dexamethasone in the stable adipogenic cell line TA1. These cells, which were derived from 5-azacytidine-treated 10T1/2 mouse embryo fibroblasts, undergo differentiation in culture after reaching confluence. Using cDNA clones corresponding to mRNAs that are induced during adipogenesis, we find that dexamethasone elicits the precocious accumulation of differentiation-specific gene products. This effect appears to be mediated by the glucocorticoid receptor, yet unlike standard steroid inductions, most of the RNAs reach the same maximal levels in the absence of dexamethasone. Glucocorticoids thus may increase the expression of a regulatory factor required for activating the entire set of differentiation-dependent genes. We also describe a gene whose transcription is not only activated during adipogenesis, but is also specifically inducible by dexamethasone in the mature adipocyte. Moreover, the glucocorticoid responsiveness of this gene in differentiated cells appears to be dependent on its prior developmental activation.

References

Jan 1, 1985·Annual Review of Pharmacology and Toxicology·G M Ringold
Feb 1, 1985·The Journal of Cell Biology·K S CookB M Spiegelman
Dec 4, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D D Brown
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D A BernlohrT J Kelly

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Citations

Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·K D AtnipD J Donaldson
Jun 5, 2003·Molecular and Cellular Endocrinology·David J MorrisMatthew P Hardy
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S CookM D Lane
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H M WenzG M Ringold
Dec 1, 1989·Journal of the American Geriatrics Society·C Remacle, N Hauser
Jan 15, 1993·American Journal of Medical Genetics·J N BeresfordC A Smoothy
Sep 25, 2010·Experimental Biology and Medicine·Sylvia P PoulosGary J Hausman
Jan 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ji Young KimCynthia M Smas
Feb 8, 2000·Clinical Orthopaedics and Related Research·G J WangG Balian
Jul 1, 1997·The Journal of Bone and Joint Surgery. American Volume·Q CuiG Balian

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