Glucocorticoid effect on insulin sensitivity: a time frame.

Journal of Endocrinological Investigation
M ZarkovicS Savic

Abstract

It is well known that glucocorticoids induce insulin resistance, but the exact time scale in humans is not well known. The aim of the study was to determine the time scale of effects of pharmacologic doses of glucocorticoids on insulin sensitivity. Subjects were treated with repeated methylprednisolone infusions and oral prednisone for Graves' orbitopathy. Insulin sensitivity was determined using euglycemic hyperinsulinemic clamp (EHGC) before, during the first glucocorticoid infusion and after 2 months of treatment. EHGC started 2 h after the start of the glucocorticoid infusion, and lasted for 2 h. In another group of patients, insulin sensitivity was determined by short insulin tolerance test (SITT) before and during the first glucocorticoid infusion. SITT started 15 min after the start of the glucocorticoid infusion and lasted for 15 min. Ten subjects were included in each protocol. All were euthyroid during the study period. Four hours after the start of the glucocorticoid infusion significant reduction of insulin sensitivity was observed, which did not change for a further 2 months of glucocorticoid treatment [before 7.82 (95% confidence interval (CI) 5.35-10.29), first infusion, 4.93 (95% CI 2.99-6.87), after 2 months 5....Continue Reading

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Citations

Oct 23, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bethany GrommeshLisa H Fish
Jan 16, 2010·Journal of Travel Medicine·Kelly MieskeTimothy O'Brien
Oct 10, 2013·Journal of Diabetes·Antonio PerezRicardo Gomez-Huelgas
Jan 5, 2010·Journal of Diabetes Science and Technology·Philip J JohnsonVenkataseshu K Ganjam
Sep 27, 2013·High Altitude Medicine & Biology·Paul Richards, David Hillebrandt
Sep 18, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Alicia Valverde-MegíasJulián García-Feijoo
Feb 22, 2013·The Journal of Clinical Endocrinology and Metabolism·Jonathan M HazlehurstJeremy W Tomlinson
Mar 14, 2018·Diabetes Research and Clinical Practice·Aldo Bonaventura, Fabrizio Montecucco

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