Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Benno RoozendaalJ L McGaugh

Abstract

Previous findings indicate that administration of abeta-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that beta-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids on memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta,17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU 28362) (15 ng) infused into the hippocampus of male Sprague Dawley rats 60 min before water maze retention testing, 24 hr after training, impaired probe trial retention performance, as assessed by quadrant search time and initial latency to cross the platform location. Because we found previously that RU 28362 infused into the hippocampus does not affect water maze acquisition or immediate recall, the findings suggest that the GR agonist-induced retention impairment was attributable to a selective influence on long-term memory retrieval. Likewise, systemic injections of the beta1-adrenoceptor partial agonist xamoterol (3.0 or 10.0 mg/kg, s.c.) 60 min before the probe trial dose-dependently impaired retention performance. The beta-adrenoceptor antagonist propranolo...Continue Reading

Citations

Jun 26, 2007·Psychopharmacology·René HurlemannRaymond J Dolan
Aug 16, 2008·Psychopharmacology·James L McGaugh, Benno Roozendaal
Dec 5, 2008·Psychopharmacology·Christophe PiérardDaniel Béracochéa
Oct 12, 2012·Psychopharmacology·Irit Akirav, Mouna Maroun
Jun 14, 2006·Behavioral Neuroscience·Victoria E BecknerDavid C Mohr
Nov 30, 2011·Behavioral Neuroscience·Benno Roozendaal, James L McGaugh
Nov 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li-Yan ZhaoLin Lu
Jan 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen M AlseneVaishali P Bakshi
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rodolphe DoreyDaniel Béracochéa
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel YehudaJames Schmeidler
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Piray AtsakBenno Roozendaal
Feb 9, 2012·Molecular & Cellular Proteomics : MCP·Kim HenningsenOve Wiborg
Jan 22, 2009·Memory·Marieke S TollenaarWalter Everaerd
Jul 22, 2008·The American Journal of Bioethics : AJOB·Donald W PfaffElena Choleris
May 18, 2006·Learning & Memory·Kevin Bolding, Jerry W Rudy
Sep 23, 2008·Occupational and Environmental Medicine·M ElovainioM Kivimäki
Jan 26, 2011·Journal of Cognitive Neuroscience·Steffen GaisJan Born
Jun 29, 2013·Journal of Cognitive Neuroscience·Sandra AckermannBjörn Rasch
Jan 5, 2011·PLoS Biology·Karel JežekAndré A Fenton
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keith SchutskySteven A Thomas
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rupshi Mitra, Robert M Sapolsky
Feb 5, 2014·Cognitive, Affective & Behavioral Neuroscience·Lars Schwabe, Oliver T Wolf
Dec 7, 2007·Neural Plasticity·Carmen Sandi, M Teresa Pinelo-Nava
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bruce S McEwen
Oct 13, 2006·Stress : the International Journal on the Biology of Stress·N Y L OeiB Bermond
Jun 7, 2006·Stress : the International Journal on the Biology of Stress·Jeansok J KimTherese A Kosten
May 10, 2008·Stress : the International Journal on the Biology of Stress·T SmeetsH Merckelbach
Jun 15, 2011·Stress : the International Journal on the Biology of Stress·Jeffrey G Tasker, James P Herman
Nov 14, 2007·Stress : the International Journal on the Biology of Stress·Donald W PfaffAna C Ribeiro
Aug 31, 2011·Stress : the International Journal on the Biology of Stress·Yongfu WangJing-Xia Cai
Jan 23, 2016·Annals of the New York Academy of Sciences·Stephanie A Gagnon, Anthony D Wagner
Apr 16, 2013·Neurobiology of Learning and Memory·Shijia LiChristiane M Thiel
Jan 22, 2013·Psychoneuroendocrinology·Dorothée BentzDominique J-F de Quervain
Feb 18, 2016·Neural Plasticity·Freddy Jeanneteau, Margarita Arango-Lievano

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