PMID: 11897997Mar 19, 2002Paper

Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium

The Journal of Allergy and Clinical Immunology
M O AksoyS G Kelsen

Abstract

Activation of the beta(2)-adrenergic receptor (beta(2)AR) system expressed by human airway epithelial cells elicits a variety of cyclic adenosine monophosphate (cAMP)-dependent processes that help determine airway caliber and the intensity of airway inflammation in asthma. Glucocorticoids, mainstays in the treatment of asthma, profoundly affect the expression and function of the beta(2)-adrenergic receptor-adenylyl cyclase (beta(2)AR-AC) system in a variety of cell types. However, the effects of glucocorticoids on the beta(2)AR-AC system expressed by human airway epithelial cells are unstudied. We examined the effects of dexamethasone (DEX) on beta(2)AR gene expression and the function of the beta(2)AR-AC system in cultured human airway epithelial cells. Studies were performed in normal airway epithelial cells and BEAS-2B cells. Beta(2)AR gene expression was assessed from measurements of beta-adrenergic receptor density, beta(2)AR mRNA, and the activity of a full-length beta(2)AR promoter-luciferase reporter construct. The function of the beta(2)AR-AC system was assessed from cAMP production in response to the beta(2)-agonist isoproterenol and the expression of the stimulatory G protein G(alpha)s. DEX had no effect on beta-adre...Continue Reading

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Citations

Jun 6, 2006·The Journal of International Medical Research·R González-SánchezA Elizalde
Jun 10, 2011·International Archives of Allergy and Immunology·Yukiko HiraguchiTakao Fujisawa
Dec 10, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·George KingGarth L Maker
Dec 30, 2017·Journal of Neonatal-perinatal Medicine·Corrie J Alonzo, Karen D Fairchild
Oct 30, 2009·COPD·Kai M Beeh, Thomas Glaab
Nov 21, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alfredo PanebraStephen B Liggett
Nov 30, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F Ochoa-CortesS J Vanner
Jul 28, 2020·International Immunology·Akihiro Shimba, Koichi Ikuta
Aug 21, 2020·Seminars in Respiratory and Critical Care Medicine·James A RussellNiranjan Kissoon
Oct 16, 2020·Immunity·Henrique G ColaçoLuís F Moita
Nov 28, 2013·The Journal of Allergy and Clinical Immunology·Ann Chen WuKelan Tantisira
Jun 2, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Pekka HurmeTuomas Jartti
Jul 6, 2010·Pulmonary Pharmacology & Therapeutics·Getu AbrahamFritz R Ungemach
Aug 3, 2010·The Journal of Allergy and Clinical Immunology·Ying JinL Keoki Williams

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