Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia

Fertility and Sterility
H YazawaT Nakada

Abstract

To evaluate the effect of dexamethasone, a potent synthetic glucocorticoid hormone, on apoptosis of testicular germ cells and vascular neutrophil adhesion after repair of testicular torsion in rats. Controlled laboratory study. Department of Urology, Yamagata University School of Medicine, Yamagata, Japan. Fifty-one male Sprague-Dawley rats. Dexamethasone, 10 mg/kg of body weight. Testicular germ-cell apoptosis (percentages of apoptotic tubules and apoptotic cells) and vascular neutrophil adhesion were assessed by using DNA nick-end labeling and the endothelial-neutrophil adhesion score, respectively. Intravenous administration of dexamethasone at repair of 90-minute testicular torsion significantly inhibited testicular germ-cell apoptosis and vascular neutrophil adhesion. This inhibition was suppressed by intravenous injection of mifepristone, a glucocorticoid-receptor antagonist. Glucocorticoids can be administered for torsion in addition to conventional torsion repair.

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Citations

Jan 8, 2004·Emergency Medicine Clinics of North America·Chi Lee, Sean O Henderson
Mar 10, 2005·Urologia Internationalis·Haluk CeylanA Tuncay Demiryürek
Jan 13, 2016·Journal of Molecular Histology·Sevil CayliTuncay Delibasi
Sep 9, 2009·Journal of Pediatric Surgery·Müslim YurtçuMustafa Cihat Avunduk
Dec 26, 2001·Biology of Reproduction·Francisco GaytánJosé Eugenio Sánchez-Criado
Apr 26, 2019·Bioscience, Biotechnology, and Biochemistry·Eri IchikawaDai Hirata

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