Glucocorticoid impairs growth of kidney outer medulla and accelerates loop of Henle differentiation and urinary concentrating capacity in rat kidney development

American Journal of Physiology. Renal Physiology
Jane StubbeBoye L Jensen

Abstract

In the rat, urinary concentrating ability develops progressively during the third postnatal (P) week and nearly reaches adult level at weaning (P21) governed by a rise in circulating glucocorticoid. Elevated extracellular osmolality can lead to growth arrest of epithelial cells. We tested the hypothesis that supranormal exposure of rat pups to glucocorticoid before the endogenous surge enhances urinary concentrating ability but inhibits renomedullary cell proliferation. Proliferating-cell nuclear antigen (PCNA)-positive cells shifted from the nephrogenic zone in the first postnatal week to Tamm-Horsfall-positive thick ascending limb (TAL) cells at the corticomedullary junction at P10-14. Renal PCNA protein abundance was stable in the suckling period and decreased 10-fold after weaning. Renal PCNA protein abundance decreased in response to dexamethasone (DEXA; 100 microg x kg(-1) x day(-1), P8-12). Prolonged administration of DEXA (P1-P11) reduced selectively the area and thickness of the outer medulla and the number of PCNA-positive cells. DEXA (P8-12) increased urinary and papillary osmolality in normohydrated and water-deprived pups and led to osmotic equilibrium between interstitium and urine, whereas apoptotic and GADD153-p...Continue Reading

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Citations

May 25, 2012·American Journal of Physiology. Renal Physiology·Louise C EvansMatthew A Bailey
Jan 9, 2010·Journal of the American Society of Nephrology : JASN·Kirsten MadsenBoye L Jensen
Nov 13, 2009·Kidney International·Kirsten MadsenBoye L Jensen
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Dec 13, 2006·Biochemical and Biophysical Research Communications·Susanne UllrichFlorian Lang
May 1, 2007·American Journal of Obstetrics and Gynecology·Roy MansanoMichael G Ross
Feb 22, 2012·Organogenesis·Renfang Song, Ihor V Yosypiv
Dec 20, 2007·American Journal of Hypertension·Johan SällströmA Erik G Persson
Sep 12, 2009·Pediatric Research·Willem B de VriesMatthijs F M van Oosterhout
May 6, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mette StæhrBoye L Jensen
Jul 15, 2016·American Journal of Physiology. Renal Physiology·Anne R TinningKirsten Madsen
Jun 22, 2007·American Journal of Physiology. Renal Physiology·Jane StubbeBoye L Jensen
Nov 18, 2011·American Journal of Physiology. Renal Physiology·Gitte KjaersgaardBoye L Jensen

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