PMID: 2985009Jan 1, 1985

Glucocorticoid-induced alteration of beta-adrenergic adenylate cyclase response of epidermis

Archives of Dermatological Research
A Ohkawara, H Iizuka


It has been reported that the beta-adrenergic adenylate cyclase system of the pig epidermis is regulated by glucocorticoids, resulting in the augmentation of epinephrine-induced cyclic-AMP accumulations. Using this phenomenon, we compared the glucocorticoidal potency of three typical glucocorticoids: hydrocortisone, prednisolone and dexamethasone. There was a considerable variation in the magnitude of the glucocorticoid-induced augmentation of the beta-adrenergic response when pig skin that had been obtained on different occasions was used. In each experimental series (using the same pig skin), however, the maximal augmentation effects obtained with these glucocorticoids were approximately the same. The potent glucocorticoid, dexamethasone, demonstrated its effect at lower concentrations than were required for prednisolone, while hydrocortisone required a much higher concentration before its effect was detectable. Thus, despite considerable variations in the magnitude of the glucocorticoid effects, the concentrations required for the glucocorticoid effect were closely associated with the established glucocorticoidal potency which has previously been described.


Jan 1, 1991·Archives of Dermatological Research·Y HashimotoH Iizuka
Jul 1, 1986·Clinical and Experimental Dermatology·H IizukaA Ohkawara


Jun 23, 1976·Biochimica Et Biophysica Acta·K Iizuka HadachiV Levine
Mar 1, 1975·The British Journal of Dermatology·K YoshikawaV Levine
Jun 1, 1976·The British Journal of Dermatology·K YoshikawaV Levine
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Jun 1, 1981·The Journal of Investigative Dermatology·H IizukaY Miura
Jun 1, 1983·The Journal of Investigative Dermatology·H Iizuka, A Ohkawara
Aug 1, 1983·The Journal of Dermatology·H IshizawaA Ohkawara
Feb 1, 1982·The Journal of Investigative Dermatology·E H Epstein, J M Bonifas
Mar 1, 1982·The British Journal of Dermatology·A Hughes, H J Yardley
Sep 1, 1981·The British Journal of Dermatology·T AoyagiY Miura

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Glucocorticoids, Systemic
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Beta-adrenergic receptor
Adenylyl Cyclase 9
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