PMID: 18209880Jan 23, 2008Paper

Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects

Arquivos brasileiros de endocrinologia e metabologia
Gherardo MazziottiJohn P Bilezikian

Abstract

Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. Fractures, which are often asymptomatic, may occur in as many as 30-50% of patients receiving chronic glucocorticoid therapy. Vertebral fractures occur early after exposure to glucocorticoids, at a time when bone mineral density (BMD) declines rapidly. Fractures tend to occur at higher BMD levels than in women with postmenopausal osteoporosis. Glucocorticoids have direct and indirect effects on the skeleton. They impair the replication, differentiation, and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes. These effects lead to a suppression of bone formation, a central feature in the pathogenesis of GIO. Glucocorticoids also favor osteoclastogenesis and as a consequence increase bone resorption. Bisphosphonates are the most effective of the various therapies that have been assessed for the management of GIO. Anabolic therapeutic strategies are under investigation. Teriparatide seems to be also efficacious for the treatment of patients with GIO.

References

Dec 1, 1991·Journal of Medical Ethics·J Harris
Jul 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M BeardB L Riggs
Jan 1, 1989·The Journal of Clinical Investigation·E CanalisT L McCarthy
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Apr 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H SamuelsG R Mundy
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M LuntA J Silman
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A ShiraishiE Ogata
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M ReidJ P Devogelaer
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A OleksikP Lips
Jul 27, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N E LaneC D Arnaud
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P van StaaC Cooper
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M S CooperP M Stewart
Sep 29, 2001·The New England Journal of Medicine·E IsraelM S LeBoff
Feb 15, 2002·The New England Journal of Medicine·Edward Kerwin
Mar 15, 2002·Frontiers of Hormone Research·F ManelliA Giustina
Mar 16, 2002·The Annals of Pharmacotherapy·John A Dougherty
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark S CooperPaul M Stewart
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shreyasee AminDavid T Felson
Aug 27, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S LekamwasamK T Khaw
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Mishaela R Rubin, John P Bilezikian
Oct 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Richard B HubbardAnne E Tattersfield
Jan 25, 2003·The American Journal of Medicine·Don D SinS F Paul Man
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q RehmanN E Lane
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Philip N SambrookGeoff C Nicholson
Jul 10, 2003·Autoimmunity Reviews·Nathalie Franchimont, Ernesto Canalis
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cynthia A LuppenBaruch Frenkel
Aug 9, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Adi Cohen, Elizabeth Shane
Sep 19, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mikayel GrigoryanHarry K Genant
Oct 24, 2003·Nature·L M CalviD T Scadden
Feb 6, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Michael SteinbuchStanley Cohen

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Osteoporosis Reports·Robert A Adler
Feb 1, 2010·Therapeutic Advances in Musculoskeletal Disease·René Rizzoli
Oct 11, 2011·Pediatric Clinics of North America·Saroj NimkarnMaria I New
Feb 16, 2010·Bone·Mônica Longo de OliveiraMarise Lazaretti-Castro
Dec 1, 2009·Endocrinology and Metabolism Clinics of North America·Saroj NimkarnMaria I New
Apr 29, 2009·Forensic Science International : Synergy·Eun Young KimSung Nam Cho
Apr 21, 2009·The American Journal of Medicine·Clifford J Rosen, Anne Klibanski
May 23, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Byung Dae LeeHyo Deog Rim
Nov 2, 2013·The Journal of Allergy and Clinical Immunology·Bjoern BuehringWilliam Busse
Nov 18, 2008·Journal of Pediatric Hematology/oncology·Zühal Keskin YildirimCahit Karakelleoğlu
Jan 1, 2009·Expert Review of Endocrinology & Metabolism·Karen Lin-SuMaria I New
May 17, 2018·Archives of Endocrinology and Metabolism·Mira SiderovaAleksandra Tsukeva
Jun 2, 2017·Journal of Tissue Engineering and Regenerative Medicine·Su Hee KimYoungmee Jung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S C Manolagas, R S Weinstein
Wiener medizinische Wochenschrift
Jaroslav Blahos
© 2021 Meta ULC. All rights reserved