Glucocorticoid induces micro-fat embolism in the rabbit: a scanning electron microscopic study

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Kiyokazu FukuiTadami Matsumoto

Abstract

The objective was to identify fat emboli in the arterioles of the femoral bone marrow by scanning electron microscopy (SEM) after glucocorticoid administration. Female adult rabbits weighing 3.5-4.0 kg received a single injection of prednisolone at a dose of 4 mg/kgBW. The day after injection was designated as day 1. Control rabbits were injected with only physiological saline and killed on day 14. The femoral bone marrow was obtained on days 5, 8, and 14, and processed for SEM. Aortic blood serum was passed through a filter, and the filter was processed for SEM. Some SEM specimens were embedded in a plastic resin and sectioned for correspondence of SEM-photomicroscopy (PM) or SEM-transmission electron microscopy (TEM). In the controls, small fat globules were present in sinusoids and venules but were absent from the arterioles. On day 5, fat globules were found in the lumina of both sinusoids and arterioles, possibly due to the effect of glucocorticoid. Complete arteriolar occlusion was not found. On day 8, fat globules were often encountered in the venous and arteriolar lumina. Some small arterioles were completely occluded by fat emboli. On day 14, fat globules were present in the arterioles, and some small and large arterio...Continue Reading

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Citations

Dec 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·John A HandalSolomon P Samuel
Jan 1, 2014·Japan Journal of Nursing Science : JJNS·Minako HabaraTokifumi Majima
Apr 12, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Toshikazu KuboHiroyoshi Fujiwara
May 2, 2017·The Journal of International Medical Research·Qiankun ZhangLie Jin
May 20, 2020·Scientific Reports·Marina ArreguiYara Bernaldo de Quirós
Jul 1, 2016·Biomedical Research·Tatsuya FukushimaMakoto Osaki

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