Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Frontiers in Endocrinology
Elina AkalestouGuy A Rutter

Abstract

Glucocorticoids are steroid hormones produced by the adrenal cortex and are essential for the maintenance of various metabolic and homeostatic functions. Their function is regulated at the tissue level by 11β-hydroxysteroid dehydrogenases and they signal through the glucocorticoid receptor, a ligand-dependent transcription factor. Clinical observations have linked excess glucocorticoid levels with profound metabolic disturbances of intermediate metabolism resulting in abdominal obesity, insulin resistance and dyslipidaemia. In this review, we discuss the physiological mechanisms of glucocorticoid secretion, regulation and function, and survey the metabolic consequences of excess glucocorticoid action resulting from elevated release and activation or up-regulated signaling. Finally, we summarize the reported impact of weight loss by diet, exercise, or bariatric surgery on circulating and tissue-specific glucocorticoid levels and examine the therapeutic possibility of reversing glucocorticoid-associated metabolic disorders.

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Citations

Jul 16, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nadezhda D Goncharova
Aug 19, 2020·Journal of Clinical Medicine·Carlos López-GómezEduardo García-Fuentes
Sep 10, 2020·International Journal of Molecular Sciences·Ahmed M El-ShehawiMona M Elseehy
Oct 29, 2020·European Child & Adolescent Psychiatry·Altanzul NarmandakhAlbertine J Oldehinkel
Nov 17, 2020·Frontiers in Genetics·Shaza AsifKyoung-Han Kim
Jan 14, 2021·International Journal of Molecular Sciences·Carine BeaupereGhislaine Guillemain
Mar 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Elena V VarlamovMaria Fleseriu
Apr 28, 2021·Journal of Diabetes and Its Complications·Pinar Gumus BalikciogluStuart Chalew
May 1, 2021·Frontiers in Medicine·Clara García-CarroMaria José Soler
Jul 25, 2021·International Journal of Molecular Sciences·Clare MacLeodMark Nixon
Sep 4, 2021·Veterinary World·Shirly GunawanVivian Soetikno

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Methods Mentioned

BETA
gastric bypass

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