Glucocorticoid modulates vasodilator response of mesenteric arterioles in spontaneously hypertensive rats

Hypertension
H SuzukiG W Schmid-Schönbein

Abstract

We previously reported that the response of the arterioles in spontaneously hypertensive rats (SHR) to histamine is blunted compared with that in normotensive control rats (Wistar-Kyoto rats [WKY]). The present study was designed to analyze the extent to which this blunted arteriolar response may be attributed in SHR to the concurrent elevation of circulating glucocorticoids through the use of adrenalectomy with and without dexamethasone supplementation. Mesenteric arterioles were observed by intravital microscopy under general anesthesia, and their lumen diameters were measured after histamine superfusion. The concentration-response curve with histamine was compared with that of an endothelium-independent vasodilator, sodium nitroprusside. At the end of each experiment, papaverine was applied topically to determine the maximal diameter for each vessel, from which a measure of arteriolar tone could be computed. The arteriolar tone in sham-operated SHR is set at a higher steady-state level than in sham-operated WKY. The concentration required for a 50% dilator response (EC50) of histamine in adrenalectomized SHR was restored to the level of WKY. Adrenalectomy did not significantly affect the EC50 of histamine in WKY. When adrena...Continue Reading

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Citations

May 9, 2012·Medical & Biological Engineering & Computing·Ming Yang, Walter L Murfee
Jan 1, 1997·Life Sciences·S C Langley-Evans
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SuzukiG W Schmid-Schönbein
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·M A Boegehold
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·S C SchäferH-A Lehr
Oct 5, 2002·Biological Research for Nursing·Brett M Mitchell, R Clinton Webb
Apr 20, 1999·Journal of Gastroenterology and Hepatology·H SuzukiG W Schmid-Schönbein
Jun 11, 1999·The American Journal of Physiology·H SuzukiG W Schmid-Schönbein
Jun 1, 1996·Nutrition Reviews·S Langley-Evans, A Jackson
Sep 23, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Frank A DeLanoGeert W Schmid-Schönbein

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