Glucocorticoid Negative Feedback in Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Rhesus Monkeys With Various Types of Adaptive Behavior: Individual and Age-Related Differences

Frontiers in Endocrinology
N D GoncharovaT E Oganyan

Abstract

The study of the mechanisms underlying the increased vulnerability of the individual to stressful environmental factors in different age periods is of great relevance for prevention and effective treatment of stress-dependent diseases that are widespread in the population of aging individuals. The purpose of our study was to investigate the individual and age-related features of the glucocorticoid negative feedback in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, the key adaptive neuroendocrine system, in experiments with physically healthy young and old female rhesus monkeys with administration of mineracorticoid receptor (fludrocortisone) and glucocorticoid receptor (dexamethasone) agonists. We studied the monkeys with increased trait anxiety and depression-like behavior (DAB) characterized, as previously was shown, by the increased vulnerability to acute stress and the animals with normal standard behavior (SB) as the control. The pronounced individual differences in the reaction of HPA axis to fludrocortisone and dexamethasone in young animals were found. Young animals with DAB showed a lower sensitivity of HPA axis to the inhibitory effect of both fludrocortisone and dexamethasone compared with young animals...Continue Reading

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Citations

Jul 16, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nadezhda D Goncharova
Nov 18, 2020·Social Cognitive and Affective Neuroscience·Alfonso J AlfiniJ Carson Smith
May 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Desen YangFuer Lu
Jan 14, 2021·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ioannis P Androulakis

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