Glucocorticoid receptor and Beta-adrenoceptor expression in epididymal adipose tissue from stressed rats

Annals of the New York Academy of Sciences
Elisângela Farias-SilvaRegina C Spadari-Bratfisch

Abstract

Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and beta-adrenergic protein receptors (beta-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, beta(1)-AR, and beta(3)-AR protein levels, but caused an increase in beta(2)-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.

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Sep 25, 2002·Canadian Journal of Physiology and Pharmacology·Elisângela Farias-SilvaRegina C Spadari-Bratfisch

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Citations

Jul 28, 2015·Bone·Beata Lecka-Czernik, Clifford J Rosen
Apr 19, 2011·Physiology & Behavior·D OrtolaniR C Spadari-Bratfisch
Jan 28, 2015·Physiology & Behavior·F Mousovich-NetoV M Corrêa da Costa
Jan 6, 2009·Annals of the New York Academy of Sciences·Regina C Spadari-Bratfisch, Iraides Nunes dos Santos
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·Iraídes N Santos, Regina C Spadari-Bratfisch

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