PMID: 8967782Mar 1, 1996Paper

Glucocorticoid receptor localization in human epidermal cells

Archives of Dermatological Research
M SerresD Schmitt

Abstract

Glucocorticoids, which are widely used in therapy, exert their immunosuppressive actions through specific receptors. These receptors have been characterized in cultured human skin fibroblasts and keratinocytes, but their localization in vitro and in vivo has not been established. To determine the tissue and cellular distribution of glucocorticoid receptors (GR), two specific polyclonal rabbit anti-human GR antibodies were used to detect these receptors in skin biopsy specimens, in freshly isolated and cultured human epidermal cells and in keratinocyte cell lines. Immunoreactive GR were only faintly detected in normal and abnormal differentiated cells and as well as those in the stratum granulosum and corneocytes. These immunolocalization studies were confirmed by fluorescence cell sorter analysis of isolated basal and suprabasal keratinocytes. Immunoreactive GR were highly expressed in normal cultured human keratinocytes, Langerhans cells and several cell lines whereas they were less expressed in melanocytes. Based upon these results the main targets of glucocorticoids in the epidermis appear to be basal and Langerhans cells.

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·J E Parrillo, A S Fauci
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·W B PrattF C Dalman
Mar 11, 1992·The Journal of Investigative Dermatology·L B NanneyL E King
Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M BrönnegårdJ A Gustafsson
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J Fuller
Feb 1, 1991·The American Journal of Physiology·N FarmanJ M Gasc
Feb 16, 1991·Biochimica Et Biophysica Acta·M Muller, R Renkawitz
Oct 1, 1990·Endocrinology·D Srivastava, E B Thompson
Mar 1, 1988·The Journal of Cell Biology·P BoukampN E Fusenig
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·J ViacJ Thivolet
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S W LeeA C Allison
Aug 29, 1986·Cell·V GiguèreR M Evans
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F FriedlY Ito
Mar 1, 1981·The Journal of Investigative Dermatology·M PonecE R De Kloet
Oct 1, 1983·The Journal of Investigative Dermatology·J ViacJ Thivolet
Oct 1, 1983·The Journal of Investigative Dermatology·K M LeifermanT C Spelsberg
Feb 1, 1982·The Journal of Investigative Dermatology·E H Epstein, J M Bonifas
Oct 1, 1980·The Journal of Investigative Dermatology·M PonecJ A Kempenaar
Mar 8, 1995·Biochemical and Biophysical Research Communications·Y M Ning, E R Sánchez
Jan 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M E Rafestin-OblinA Vandewalle

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Citations

Aug 15, 1998·Mediators of Inflammation·A Ahluwalia
Sep 22, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hidetaka KumagamiHaruo Takahashi
Jan 22, 2013·Cellular and Molecular Life Sciences : CMLS·Xiao-Yong ManMin Zheng
Dec 2, 2015·Experimental and Therapeutic Medicine·Xiaowen PangGuangjin Guo
Apr 17, 2004·The Journal of Investigative Dermatology·Wolfram HoetzeneckerAdelheid Elbe-Bürger
Mar 20, 2009·The Journal of Investigative Dermatology·Simone MeindlAdelheid Elbe-Bürger
Jul 4, 2003·The Journal of Investigative Dermatology·Kaori InoueToru Tsuchiya
Oct 27, 2004·Chemico-biological Interactions·Hollie I Swanson
Jul 13, 2007·Biochemical and Biophysical Research Communications·Xavier DezitterThierry Idziorek
Jan 8, 2005·The Veterinary Clinics of North America. Equine Practice·Philip J JohnsonJohn M Kreeger
Mar 25, 2015·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Christine R LattinL Michael Romero
Jul 28, 1999·International Immunology·R SacedónA G Zapata
Apr 5, 2017·Journal of Cosmetic Dermatology·Sahar El Sayed YoussefManal Hassan Moussa
Jun 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natsuho ItoRalf Paus
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Jul 1, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Iris R HartleyConstantine A Stratakis
Dec 13, 2016·Reviews in Endocrine & Metabolic Disorders·Constantine A Stratakis
Aug 21, 2001·The Journal of Investigative Dermatology·S KapasP M Farthing

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