Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training

PloS One
Garrett I AshLinda S Pescatello

Abstract

Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) pre- and post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes. We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol's actions in muscle tissue as they interact with sex differences in cortisol production.

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Citations

Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Agnieszka SwiecickaMartin K Rutter
Apr 25, 2019·International Journal of Molecular Sciences·Paula Paccielli FreireRobson Francisco Carvalho
Jul 22, 2020·International Journal of Sports Medicine·Javier Alvarez-RomeroDanielle Hiam
Apr 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher G VannMichael D Roberts

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Methods Mentioned

BETA
genotyping

Software Mentioned

SAS
Matlab
SPSS
FAMuSS

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