PMID: 9191978Feb 1, 1997Paper

Glucocorticoid receptors and actions in the spinal cord of the Wobbler mouse, a model for neurodegenerative diseases

The Journal of Steroid Biochemistry and Molecular Biology
M C González DeniselleA F De Nicola

Abstract

We have studied glucocorticoid receptors (GR) and actions in the spinal cord of the Wobbler mouse, a model for amyotrophic lateral sclerosis and infantile spinal muscular atrophy. Basal and stress levels of circulating corticosterone (CORT) were increased in Wobbler mice. Single point binding assays showed that cytosolic type II GR in the spinal cord of Wobbler mice of both sexes were slightly reduced compared with normal littermates. Saturation analysis further demonstrated a non-significant reduction in Bmax with increased Kd. In the hippocampus, however, we found down-regulation of GR, a probable response to increased CORT levels. We also found that the basal activity of ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was higher in Wobbler mice than in control animals. Both groups showed a two-fold stimulation of ODC activity after treatment with dexamethasone (DEX). Additionally, Wobbler mice presented with an intense proliferation of astrocytes immunoreactive (ir) for glial fibrillary acidic protein (GFAP) in grey and white matter of the spinal cord. The enhanced GFAP-ir was attenuated after four days of treatment with a corticosterone (CORT) pellet implant, producing a pharmacological incr...Continue Reading

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Citations

Apr 18, 2009·Cellular and Molecular Neurobiology·Wei-Bing XuLian-Shun Jia
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A F De NicolaE R de Kloet
Aug 31, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan A FidlerJames C Dodge
Jun 16, 2010·Acta Neurologica Scandinavica·G Gargiulo MonachelliM C González Deniselle
Nov 20, 2012·Journal of Neuroendocrinology·M MeyerA F De Nicola
Feb 26, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Maria MeyerAlejandro F De Nicola
Jul 23, 2013·Brain Research·Eric R DeutschDavid W Wright
Apr 5, 2020·International Journal of Molecular Sciences·Alejandro F De NicolaMaria Claudia Gonzalez Deniselle
Jan 8, 2021·Molecular Neurobiology·Agustina LaraMaria Claudia Gonzalez Deniselle

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