Glucocorticoid receptors in lung cancer: new perspectives

The Journal of Endocrinology
Kerryn Marilyn TaylorPaula Sommer

Abstract

Proper expression of the glucocorticoid receptor (GR) plays an essential role in the development of the lung. GR expression and signaling in the lung is manipulated by administration of synthetic glucocorticoids (Gcs) for the treatment of neonatal, childhood and adult lung diseases. In lung cancers, Gcs are also commonly used as co-treatment during chemotherapy. This review summarises the effect of Gc monotherapy and co-therapy on lung cancers in-vitro, in mouse models of lung cancer, in xenograft, ex-vivo and in-vivo. The disparity between the effects of pre-clinical and in-vivo Gc therapy are commented on in light of the recent discovery of the GR as a novel tumour suppressor gene.

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