Glucocorticoids and the Risk of Peptic Ulcer Bleeding: Case-Control Analysis Based on Swiss Claims Data

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Daphne ReinauChristoph R Meier

Abstract

Controversy exists as to whether glucocorticoids (GC) are ulcerogenic per se and may thus cause peptic ulcer bleeding (PUB) independent of concomitantly prescribed nonsteroidal anti-inflammatory drugs (NSAIDs). To investigate the association between GC use and PUB with or without co-medication with NSAIDs. We conducted a case-control study using administrative claims data from the Swiss health insurance company Helsana. We identified 1191 cases with incident PUB between 2012 and 2016 and matched up to 10 PUB-free controls to each case on age, sex, region and number of years insured with Helsana. We compared prior GC exposure between cases and controls using multivariate conditional logistic regression analyses controlling for several potential confounders. Patients with or without concomitant NSAID exposure were analysed separately. Patients with prior exposure to both GC and NSAIDs were five times more likely to experience PUB than patients who neither used GC nor NSAIDs (adjusted odds ratio [adj. OR] 4.80, 95% CI 3.55-6.71). Although the risk of PUB among patients who used NSAIDs without GC was increased threefold (adj. OR 3.20, 95% CI 2.59-3.95), we observed only a moderately increased risk among patients who used GC alone w...Continue Reading

References

Sep 1, 1991·The American Journal of Medicine·J L CarsonE Sim
May 1, 1991·Annals of Internal Medicine·J M PiperM R Griffin
Jun 8, 2001·American Journal of Epidemiology·S Hernández-Díaz, L A Rodríguez
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jiing C LuoChi H Cho
Feb 6, 2004·European Journal of Pharmacology·Jiing C LuoChi H Cho
Sep 8, 2012·European Journal of Clinical Pharmacology·Francisco J de AbajoLuis A García-Rodríguez
Aug 7, 2013·World Journal of Gastrointestinal Pharmacology and Therapeutics·Mario Guslandi
Mar 1, 2017·Lancet·Angel Lanas, Francis K L Chan

❮ Previous
Next ❯

Citations

Sep 12, 2018·Helicobacter·Laimas JonaitisLimas Kupcinskas
Feb 23, 2020·Nature Reviews. Rheumatology·Frank Buttgereit
Oct 14, 2020·Current Rheumatology Reports·Andriko Palmowski, Frank Buttgereit
Jul 3, 2021·Clinical Interventions in Aging·Shuying WangYuan Gong
Aug 12, 2021·Expert Opinion on Drug Safety·María-José Domper ArnalAngel Lanas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.