Glucocorticoids and vulnerability to psychostimulant drugs: toward substrate and mechanism

Annals of the New York Academy of Sciences
Inge E M de Jong, E Ronald de Kloet

Abstract

Glucocorticoid hormones can modulate the propensity of individuals to develop addictive behavior and, by doing so, contribute to the existence of individual differences in vulnerability to drugs. This article summarizes recent findings that increase our knowledge about drug-induced neuronal adaptations in the brain reward system and the role glucocorticoids may play in this process. Evidence exists that drugs and stress can induce similar changes in excitatory synaptic strength within the mesolimbic dopamine system, suggesting a coordinate mechanism for drugs of abuse and glucocorticoids. The glucocorticoid receptor (GR) plays an essential role in the stress-induced synaptic alterations, and studies using transgenic mice suggest that the GR is a key modulator of the motivation to take drugs and of the behavioral effects of repeated drug intake. The current state of research into the interplay between glucocorticoid hormones and addiction has reached a new phase in which detailed cellular and molecular analyses of the actual mechanisms will become possible. An important role is assigned to the GR, although many issues remain to be addressed, such as the actual site of glucocorticoid action in the brain, the molecular mechanisms ...Continue Reading

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Citations

Oct 16, 2007·Psychopharmacology·Daniel BéracochéaChristophe Piérard
May 19, 2011·Psychopharmacology·Lucia CaffinoFabio Fumagalli
Feb 4, 2012·Cellular and Molecular Neurobiology·Brent MyersJames P Herman
May 6, 2009·Addiction Biology·Satu J SiiskonenBruno H Ch Stricker
Mar 7, 2009·Psychopharmacology·Inge E M de JongE Ronald de Kloet
Jan 6, 2009·European Journal of Pharmacology·Inge E M de Jong, E Ronald de Kloet
Jun 26, 2007·Psychoneuroendocrinology·A Courtney DeVriesJessica K Alexander
Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Dipesh ChaudhuryMing-Hu Han
Aug 14, 2012·The European Journal of Neuroscience·Maria A EsparzaLiliana M Cancela
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Nov 29, 2005·Molecular and Cellular Endocrinology·Kathleen Van CraenenbroeckGuy Haegeman
Mar 10, 2015·Physiology & Behavior·Ann E Egan, Yvonne M Ulrich-Lai
Sep 26, 2012·Advances in Pharmacological Sciences·Naila Rasheed, Abdullah Alghasham
Jul 9, 2014·Psychoneuroendocrinology·Estrella R MontoyaJack van Honk
Jun 16, 2016·Frontiers in Cellular Neuroscience·Menahem B Doura, Ellen M Unterwald
Jul 15, 2015·Behavioural Pharmacology·Vincent DidoneEtienne Quertemont
Jan 30, 2016·Molecular Psychiatry·C Garcia-KellerP W Kalivas
Aug 21, 2021·The American Journal on Addictions·Shadab ForouzanTherese A Kosten

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