Glucocorticoids as an adjunct to oncologic treatment in solid malignancies - Not an innocent bystander

Critical Reviews in Oncology/hematology
Corinne Maurice-DrorGil Bar-Sela

Abstract

Glucocorticoids are steroidal hormones which exert their action via genomic and non-genomic mechanisms. In the clinical setting, glucocorticoids are utilized for their anti-inflammatory, anti-allergenic and immunomodulatory effects and for their well-established, pro-apoptotic effects on hematological malignancies. In the treatment of solid tumors, glucocorticoids serve primarily for alleviation of tumor- and treatment-related symptoms and in most cases are not considered to have a direct effect on tumor growth and spread. However, significant pre-clinical data suggest that glucocorticoids have diverse effects on tumor progression, both pro- and anti- tumorigenic. In contrast, the clinical data regarding the pro- and anti-tumorigenic effects of glucocorticoids on solid tumors is scarce, and summarized in this review. The following review presents the suggested glucocorticoids mechanism of action and the effects of glucocorticoids on tumor cells, on the tumor microenvironment and on tumor response to cytotoxic therapy, in the pre-clinical and clinical settings.

Citations

Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Oct 30, 2020·The Journal of Biological Chemistry·Shuhei SuzukiChifumi Kitanaka
Jan 18, 2021·The Journal of Biological Chemistry·Shuhei SuzukiChifumi Kitanaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society
Y Z Chen, J Qiu
The American Journal of Medicine
M A LaCombe
Archives of Internal Medicine
Allen R NissensonRobert W Dubois
© 2022 Meta ULC. All rights reserved