Glucocorticoids change the ratio of type III to type I procollagen extracellularly

Collagen and Related Research
S Shull, K R Cutroneo

Abstract

Rat skin fibroblasts were treated with dexamethasone and labeled with radioactive proline for 2 hours. Intracellular and extracellular procollagens were immunoprecipitated with monospecific polyclonal antibodies. Both intracellular and extracellular types I and III procollagen were decreased coordinately by glucocorticoid treatment. The ratio of type III to type I procollagen was the same for control and dexamethasone-treated cell cultures. However, when rat skin fibroblasts were prelabeled with radioactive proline and chased in the presence of unlabeled proline the ratio of type III to type I extracellular procollagens remained constant in the glucocorticoid-treated cells and increased in control fibroblasts.

References


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Citations

Nov 25, 2006·Thyroid : Official Journal of the American Thyroid Association·Parviz YazdanparastJan Faergemann
Jul 1, 1990·Matrix : Collagen and Related Research·K P Mintz, K G Mann
Apr 20, 2004·Journal of Cellular Biochemistry·Kenneth R Cutroneo, Kenneth M Sterling
May 13, 2006·Experimental Dermatology·Stefanie SchoepeKhusru Asadullah

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