Glucocorticoids, hyperinsulinemia, and fetal lung maturation

American Journal of Obstetrics and Gynecology
J C BeckD L Sly

Abstract

Glucocorticoids are reported to accelerate fetal lung development, whereas insulin is alleged to interfere with this effect of glucocorticoids. A paradox exists, however, in that glucocorticoids also induce hyperinsulinemia. The purpose of this study was to explore the interrelationships of betamethasone, hyperinsulinemia, and hyperglycemia to fetal lung maturation. In this rhesus preparation, maternal betamethasone administration produced an alarming increase in maternal and fetal plasma insulin values. A significant increase in total lung volumes also occurred, but lung surfactant properties (as measured by amniotic fluid lecithin/sphingomyelin concentrations, lung alveolar deflation stability, and lung phosphatidylcholine concentrations) remained unchanged. These findings are consistent with the following hypotheses: (1) Betamethasone-induced hyperinsulinemia impairs acceleration of surfactant production but does not negate increases in maximum lung volume; (2) betamethasone-induced increases in maximum lung volume occur through mechanisms other than alveolar surfactant alterations.

References

Jan 29, 1979·Biochimica Et Biophysica Acta·R A RhoadesB Vannata
May 1, 1977·Journal of Steroid Biochemistry·P M Farrell
Oct 1, 1979·The Journal of Surgical Research·R R WolfeJ F Burke
Jun 1, 1979·Pediatric Research·N D NeufeldS A Kaplan
Dec 1, 1975·The Journal of Pediatrics·M E Avery, I Frantz
Jan 1, 1980·Pharmacology & Therapeutics·B T Smith, W G Bogues

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Citations

Dec 24, 2008·Seminars in Fetal & Neonatal Medicine·John P Newnham, Alan H Jobe
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·T Spillman, D B Cotton
Jun 1, 1986·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A LohningerW Erhardt

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