Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice

European Journal of Pharmacology
Wei-Zu LiHui-Ling Gong

Abstract

Alzheimer's disease is a chronic neurodegenerative disorder marked by a progressive loss of memory and cognitive function. Stress level glucocorticoids are correlated with dementia progression in patients with Alzheimer's disease. In this study, twelve month old male mice were chronically treated for 21 days with stress-level dexamethasone (5mg/kg). We investigated the pathological consequences of dexamethasone administration on learning and memory impairments, amyloid precursor protein processing and neuronal cell apoptosis in 12-month old male mice. Our results indicate that dexamethasone can induce learning and memory impairments, neuronal cell apoptosis, and mRNA levels of the amyloid precursor protein, beta-secretase and caspase-3 are selectively increased after dexamethasone administration. Immunohistochemistry demonstrated that amyloid precursor protein, caspase-3 and cytochrome c in the cortex and CA1, CA3 regions of the hippocampus are significantly increased in 12-month old male mice. Furthermore, dexamethasone treatment induced cortex and hippocampus neuron apoptosis as well as increasing the activity of caspase-9 and caspase-3. These findings suggest that high levels of glucocorticoids, found in Alzheimer's disease,...Continue Reading

References

Aug 1, 1997·Journal of Chemical Neuroanatomy·L P Reagan, B S McEwen
Dec 11, 1997·Nature·A P MonaghanG Schütz
Feb 24, 2001·Journal of Anatomy·C HibberdJ R Seckl
Feb 5, 2002·European Archives of Psychiatry and Clinical Neuroscience·C Höschl, T Hajek
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natasa TerzicSabera Ruzdijic
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kim N GreenFrank M LaFerla
Dec 8, 2006·The American Journal of Psychiatry·John G CsernanskyJohn C Morris
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jie ZhaoRobert Vassar
Jun 26, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Surafel MulugetaMichael F Beers
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cheryl D ConradRyan L Wright
Sep 22, 2007·European Journal of Pharmacology·Yu-You YaoWei-Ping Li
Aug 9, 2008·The American Journal of Pathology·Dun-Sheng YangRalph A Nixon

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Citations

May 25, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Rupinder K SodhiAmteshwar S Jaggi
Mar 28, 2013·Drugs & Aging·Hitomi KurinamiRyuichi Morishita
May 1, 2011·Therapeutic Advances in Chronic Disease·Arthur A SimenLisa C Barry
Mar 13, 2014·Journal of Neurosurgery. Spine·Hamed Reihani KermaniMajid Asadi-Shekaari
Aug 26, 2014·International Journal of Alzheimer's Disease·Jing XiaMonika Ray
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding
Mar 15, 2011·Medical Hypotheses·Daniel A NationJoel E Dimsdale
Sep 28, 2010·Experimental Gerontology·Marie-Christine Pardon
Jun 17, 2015·Journal of Neurochemistry·David Baglietto-VargasFrank M LaFerla
Jan 9, 2015·The International Journal of Neuropsychopharmacology·Huang HuangMing Xiao
Jan 28, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fabien LantéHélène Marie
Apr 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei-Zu LiWei-Ping Li
Apr 28, 2016·Neurochemistry International·Ana C Sánchez-HidalgoRocío M de Pablos
Nov 6, 2018·Acta Biochimica Et Biophysica Sinica·Lingyan MaZhengwei Fu
Nov 28, 2019·Journal of Alzheimer's Disease : JAD·Michael NeriusAnja Schneider
Oct 19, 2019·Current Drug Targets·Vivek Kumar Sharma, Thakur Gurjeet Singh
Nov 28, 2016·Molecular Neurobiology·Mythily Srinivasan, Debomoy K Lahiri
Sep 3, 2014·Reviews in the Neurosciences·Alberto MachadoJosefina Cano
Feb 6, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·K V Anil KumarSreemantula Satyanarayana
Jan 1, 2011·Dementia & Neuropsychologia·Juliana Nery de Souza-TalaricoSonia J Lupien

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