Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid-derived suppressor cells

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hyun Ju LeeJoo Youn Oh

Abstract

Glucocorticoids (GCs) are the most widely used drugs to prevent transplant rejection; however, it is not yet clear how GCs induce immune tolerance in transplantation. Here, we demonstrate that GCs induce tolerance to corneal allografts in mice through expansion of MHC class II- CD11b+ Ly6C+ monocytes in the bone marrow and mobilization of the cells to spleen, draining lymph nodes, and graft site. The GC-induced CD11b+ Ly6C+ monocytes inhibited T cell proliferation in vitro, and adoptive transfer of the cells improved the survival of corneal allografts. Depletion of CD11b+ Ly6C+ cells in mice during GC treatment abrogated the effects of GCs in prevention of immune rejection. Together, the results identify monocytic myeloid-derived suppressor cells as crucial mediators of the GC-induced tolerance in transplantation.

References

Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Youmin KangGuoxing Zheng
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Sophie DugastBernard Vanhove
Apr 20, 2010·Molecular and Cellular Endocrinology·Agnes E Coutinho, Karen E Chapman
Jun 17, 2010·The Journal of Clinical Investigation·Mercedes Rodriguez GarciaJordi C Ochando
Sep 2, 2010·The British Journal of Ophthalmology·Noopur GuptaRadhika Tandon
Apr 27, 2012·Immunologic Research·Jordi C Ochando, Shu Hsia Chen
Aug 30, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joo Youn OhDarwin J Prockop
Sep 25, 2012·European Journal of Immunology·Guoxing ZhengAoshuang Chen
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A W Thomson, H R Turnquist
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y LuanB Murphy
Mar 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun Ju LeeJoo Youn Oh
Jul 7, 2016·Nature Communications·Vincenzo BronteDmitry I Gabrilovich
Dec 27, 2016·Frontiers in Immunology·Jose MarinoGilles Benichou
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun Jeong JeongJoo Youn Oh
Jan 20, 2018·Nature Immunology·Filippo VegliaDmitry Gabrilovich
Jan 31, 2018·Journal of Translational Medicine·Weitao ZhangMing Xu

❮ Previous
Next ❯

Citations

Sep 3, 2020·Frontiers of Medicine·Mahmoud Mohammad YaseenAmmar Daoud
Mar 22, 2019·Frontiers in Immunology·Jordi OchandoEstela Paz-Artal
Sep 7, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yuerong RenYan He
Mar 29, 2020·International Immunopharmacology·Peng CaoYong Zhao
Mar 20, 2021·Frontiers in Immunology·Nathaniel OberholtzerSatish N Nadig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.