PMID: 9191973Feb 1, 1997Paper

Glucocorticoids induce corticosteroid-binding globulin biosynthesis by immature mouse liver and kidney

The Journal of Steroid Biochemistry and Molecular Biology
X F ZhaoG L Hammond

Abstract

Marked changes in mouse corticosteroid-binding globulin (CBG) gene expression in the liver and kidney occur postnatally. To study the influence of glucocorticoids on the initiation of mouse CBG biosynthesis in these tissues during the first two weeks after birth, we administered dexamethasone (0.5 microgram/g body wt/day) to 4- and 11-day-old pups for three days. This resulted in higher serum CBG and hepatic CBG mRNA levels in animals, irrespective of their ages. Higher relative amounts of CBG mRNA in the kidneys of 14-day-old pups after three days of dexamethasone treatment co-incided with higher amounts of intact and proteolytically cleaved CGB in their urine, and both are indicative of increased CGB production by the developing renal tubules. When an additional group of 11-day-old pups (n = 4) was treated with 0.25 microgram dexamethasone/g body weight per day for five days, this also resulted in significantly higher levels of serum CBG (P < 0.01), hepatic CBG mRNA (P < 0.01) and renal CBG mRNA (P < 0.05), compared to littermates treated with the oil vehicle alone. In contrast, serum CBG levels progressively decreased in adult female mice during five days of treatment with 0.5 microgram dexamethasone/g body weight per day. T...Continue Reading

References

Sep 20, 1976·Biochemical and Biophysical Research Communications·S Yamamoto, N Ohsawa
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1977·The Journal of Endocrinology·H van BaelenP de Moor
Jun 1, 1991·Teratology·J F Crocker, M R Ogborn
Feb 1, 1991·Endocrinology·C L Smith, G L Hammond
Aug 1, 1990·Molecular Endocrinology·G E SeraliniG L Hammond
May 1, 1989·Endocrine Reviews·P L Ballard
Aug 1, 1987·Clinical Endocrinology·J A Schlechte, D Hamilton
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jul 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·G L Hammond, P L Lähteenmäki
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Oct 1, 1983·Early Human Development·B S StonestreetW Oh
Nov 1, 1995·Trends in Endocrinology and Metabolism : TEM·G L Hammond

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Citations

Sep 19, 2006·Molecular and Cellular Biology·Helle Heibroch PetersenThomas E Willnow
Nov 11, 2008·General and Comparative Endocrinology·Claudia MüllerLukas Jenni
Sep 16, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Paul Anthony DawsonDaniel Markovich
Dec 22, 1999·American Journal of Obstetrics and Gynecology·T M JeffrayJ R Challis
Oct 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daniela OgiasPatrícia Gama
May 27, 2011·The Journal of Experimental Biology·Aurélie GoutteOlivier Chastel

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