PMID: 9654058Jul 8, 1998Paper

Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation

European Journal of Biochemistry
P De VosJ Auwerx

Abstract

Leptin is a hormone which is produced in adipose tissue and which plays a role in the regulation of energy homeostasis. The expression of the ob gene, encoding leptin, is under multi-hormonal control. We have shown previously that high doses of glucocorticoids are positive regulators of leptin expression in rats and that they concomitantly reduce food intake and body mass gain in these animals. In the present report we analyse the molecular mechanism of this glucocorticoid regulation of leptin expression. In cultured rat adipocytes dexamethasone induces leptin mRNA levels, an effect not inhibited by the protein synthesis inhibitor cycloheximide. In addition, our data indicate that the induction of the expression of the leptin gene by dexamethasone is at least in part due to a transcriptional activation that is mediated by the glucocorticoid receptor. Deletion mapping of the human leptin promoter shows that cis-elements involved in the glucocorticoid effect are located between -55 and +31 relative to the transcription initiation site. Since this region does not contain a binding site for the glucocorticoid receptor, the effect does not rely on the classical molecular mechanism of glucocorticoid receptor action. A role of C/EBP a...Continue Reading

Citations

May 9, 2002·Molecular and Cellular Endocrinology·Jens M BruunBjørn Richelsen
Feb 7, 2002·The Biochemical Journal·Sophie TurbanMichèle Guerre-Millo
Nov 18, 2006·International Breastfeeding Journal·Yesim Ozarda IlcolTanju Ozkan
May 9, 2001·Biochemical and Biophysical Research Communications·M J Moreno-AliagaP J Havel
Nov 3, 2004·Domestic Animal Endocrinology·T A KoktaR A Hill
Jun 22, 2000·Biology of Reproduction·N Kronfeld-SchorE P Widmaier
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S MargeticR A Hill
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M BuyseM Lombès
Apr 2, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ole D Wolthers, Carsten Heuck
Mar 27, 2009·Journal of Pediatric Gastroenterology and Nutrition·Marianne K VihinenTaneli Raivio
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian N Finck, Rodney W Johnson
Nov 13, 2018·Molecular Biology Reports·JuHwan KimSoon Young Shin
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·P M WatsonT W Gettys

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