Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression

Endocrinology
T L Miller, K E Mayo

Abstract

Glucocorticoids regulate GH synthesis and secretion by influencing both hypothalamic and pituitary function. With respect to GH-releasing hormone (GHRH), an important GH secretagogue, glucocorticoids are reported not only to suppress hypothalamic GHRH expression but also to augment pituitary responsiveness to GHRH. To investigate further this latter observation, we have determined the effects of this steroid on expression of the GHRH receptor (GHRH-R) gene in the rat pituitary in vivo and in pituitary cells in vitro. Adult male rats were adrenalectomized or sham operated and treated with s.c. implants of cholesterol or corticosterone. Adrenalectomized animals showed substantially reduced pituitary GHRH-R mRNA levels, when compared with untreated sham-operated animals. Conversely, administration of corticosterone increased pituitary GHRH-R mRNA levels in intact, as well as adrenalectomized rats. We also analyzed the effects of the synthetic glucocorticoid, dexamethasone, on GHRH-R mRNA expression in cultured rat anterior pituitary cells. GHRH-R mRNA was significantly increased by dexamethasone, with a maximal response observed in the presence of 100 nM hormone. This dose of dexamethasone substantially elevated GHRH-R mRNA after ...Continue Reading

References

May 1, 1979·Physiology & Behavior·J S MeyerB S McEwen
Sep 2, 1976·The New England Journal of Medicine·J N Loeb
Jul 1, 1990·Molecular Endocrinology·D A Nielsen, D J Shapiro
Feb 10, 1989·Cell·M Beato
Aug 1, 1986·Endocrine Reviews·L A Frohman, J O Jansson
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D D MooreH M Goodman
Apr 1, 1987·Molecular and Cellular Biology·I Paek, R Axel
Oct 1, 1987·Acta Endocrinologica·K NakagawaK Akikawa
Aug 5, 1973·Journal of Molecular Biology·R H Singer, S Penman
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R M EvansM G Rosenfeld
Jan 1, 1994·Life Sciences·J H Thakore, T G Dinan
May 1, 1993·Molecular and Cellular Endocrinology·J KononenM Pelto-Huikko
Dec 26, 1995·Biochemical and Biophysical Research Communications·N MikiM Yamada
Jan 1, 1996·Cardiovascular and Interventional Radiology·Y KorogiM Takahashi
Dec 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·I H GOLDBERGE REICH

❮ Previous
Next ❯

Citations

Jan 7, 2011·The Journal of Clinical Endocrinology and Metabolism·Andrea S CornfordJeffrey F Horowitz
Mar 11, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Haruo Nogami, Setsuji Hisano
Mar 11, 2011·Annals of the New York Academy of Sciences·Raul M LuqueRhonda D Kineman
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A I Korytko, L Cuttler
Jun 9, 2000·Journal of Neuroendocrinology·H TamuraI Wakabayashi
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eunhee KimSeungjoon Park
Mar 19, 2015·The British Journal of Nutrition·Hassiba BenbaibecheElhadj Ahmed Koceïr
Feb 6, 2013·Nature Reviews. Endocrinology·Gherardo Mazziotti, Andrea Giustina
Feb 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Karine BédardPierrette Gaudreau
May 16, 2009·Expert Opinion on Drug Metabolism & Toxicology·Jacek Wójcikowski, Władysława Anna Daniel
Mar 3, 1998·Molecular Endocrinology·S PetersennH M Schulte
Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·C M LaskoL Cuttler
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jul 19, 2000·Journal of Neurochemistry·L F García-FernándezA Muñoz
Aug 26, 2004·American Journal of Physiology. Endocrinology and Metabolism·Maarten O van AkenFerdinand Roelfsema

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.